Document Detail


Maternal-fetal transmission of human immunodeficiency virus: a review of possible routes and cellular mechanisms of infection.
MedLine Citation:
PMID:  1420681     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prevalence of human immunodeficiency virus (HIV) infections among children is increasing in a manner that closely follows the spread of the disease among women. Despite the fact that in utero transmission via the placenta is though to play a major role in the spread of HIV to the pediatric population, little is known about the timing, route(s), and cellular mechanisms by which maternal-fetal transmission occurs. This review attempts to use a developmental and cellular approach to assess the available clinical and laboratory data pertaining to maternal-fetal HIV transmission. While much of this review focuses on the role of the placenta, particularly the placental trophoblast, on the transmission of HIV, potential routes of infection during early development are also discussed. Clinical studies indicate that the placental trophoblast can be infected with HIV but have shed no light on how the virus gains entry to this tissue. While some laboratory studies confirm that trophoblast cells and placental macrophages can be infected with HIV in vitro, many studies are difficult to interpret because of inadequate characterization of the placental cells used. The role of CD4 in the infection of trophoblast remains controversial and clearly warrants a systematic examination. It is also apparent that viral tropism has not received enough attention and more studies using different strains of HIV are required. Thus, several basic questions remain to be answered before strategies to prevent maternal-fetal transmission of HIV can be developed.
Authors:
G C Douglas; B F King
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  15     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-11-27     Completed Date:  1992-11-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  678-91     Citation Subset:  IM; X    
Affiliation:
Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis 95616-8643.
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MeSH Terms
Descriptor/Qualifier:
Female
Fetal Diseases / microbiology*
HIV / physiology*
HIV Infections / congenital,  microbiology,  transmission*
Humans
Infant, Newborn
Male
Ovum / microbiology
Placenta / microbiology*
Pregnancy
Pregnancy Complications, Infectious / microbiology*
Semen / microbiology
Trophoblasts / microbiology
Grant Support
ID/Acronym/Agency:
AI32307/AI/NIAID NIH HHS; HD11658/HD/NICHD NIH HHS
Comments/Corrections
Comment In:
Clin Infect Dis. 1993 Jun;16(6):828-9   [PMID:  8329518 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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