Document Detail

Maternal-fetal transfer of immunoglobulins.
MedLine Citation:
PMID:  7719885     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The goal of this review is to summarize the current knowledge about the transfer of immunoglobulins from the mother to the fetus. Data obtained experimentally and clinically will be discussed, and intervention trials and options will be examined. DATA SOURCE: References are limited to the English language and to human data. Sources include computerized databases and bibliographies of recent articles and books. RESULTS: Electronmicroscopic studies have unveiled the passage route of IgG through the placenta. The placental in vitro perfusion system has become a valuable experimental model, with a crucial role in the preclinical evaluation of trials to manipulate the maternal-fetal passage of immunoglobulins. CONCLUSIONS: Immunoglobulins are transferred through the placenta in an active, selective and affinity-restricted process, which is Fc-gamma receptor mediated and intracellular. Much work is still required to improve our ability to control the rate and the efficiency of this process, but the results of pioneering attempts have been encouraging.
M Landor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  74     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-05-22     Completed Date:  1995-05-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  279-83; quiz 284     Citation Subset:  IM    
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
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MeSH Terms
Immunity, Maternally-Acquired
Immunoglobulins / immunology*
Maternal-Fetal Exchange / immunology*
Placenta / immunology
Grant Support
Reg. No./Substance:

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