Document Detail

Maternal and fetal survival following surgery and chemotherapy of endodermal sinus tumor of the ovary during pregnancy: a case report.
MedLine Citation:
PMID:  2464778     Owner:  NLM     Status:  MEDLINE    
An ovarian endodermal sinus tumor was found in a patient with a 15-week intrauterine gestation. She received conservative surgery and six courses of combination chemotherapy from 16 weeks' gestation, and delivered a normal term infant at 37 weeks' gestation. Two other courses of combination chemotherapy including cisplatin were added. No residual tumor was found at subsequent exploration, and she is alive 33 months after the original diagnosis without any evidence of recurrence. We believe this is the first reported case of maternal survival past 2 years and the earliest chemotherapy done in the early second trimester of pregnancy without resulting in fetal abnormalities.
D S Kim; M I Park
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  73     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-03-23     Completed Date:  1989-03-23     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  503-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, School of Medicine, Hanyang University, Seoul, Korea.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Bleomycin / administration & dosage
Cisplatin / administration & dosage
Combined Modality Therapy
Cyclophosphamide / administration & dosage
Dactinomycin / administration & dosage
Fallopian Tubes / surgery
Infant, Newborn
Mesonephroma / mortality,  therapy*
Ovarian Neoplasms / mortality,  therapy*
Pregnancy Complications, Neoplastic / mortality,  therapy*
Vinblastine / administration & dosage
Vincristine / administration & dosage
Reg. No./Substance:
0/PVB protocol; 0/VAC protocol; 11056-06-7/Bleomycin; 15663-27-1/Cisplatin; 50-18-0/Cyclophosphamide; 50-76-0/Dactinomycin; 57-22-7/Vincristine; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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