Document Detail


Maternal and fetal single nucleotide polymorphisms in the epoxide hydrolase and gluthatione S-transferase P1 genes are not associated with pre-eclampsia in the Coloured population of the Western Cape, South Africa.
MedLine Citation:
PMID:  16147638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidative stress is thought to play an important role in the pathophysiology of pre-eclampsia. A defect in certain enzymes responsible for detoxification may cause prolonged exposure to reactive by-products and contribute to maternal endothelial as well as placental damage. Two polymorphisms affecting the function of the biotransformation enzymes epoxide hydrolase and glutathione S-transferase P1 were shown previously to be associated with pre-eclampsia in a Dutch population. The aim of this study was to determine if these two polymorphisms (maternal or fetal) contribute to pre-eclampsia in an anthropologically distinct population (the Western Cape region of South Africa) with a high incidence of the disease. Genomic DNA of mother - infant pairs with severe pre-eclampsia (n = 144), a population control group (n = 156) and control mother - infant pairs with uncomplicated pregnancy outcome (n = 45) were analysed for the EPHX and GSTP1 polymorphisms by polymerase chain reaction amplification and restriction enzyme digestion. Each polymorphism had a similar distribution in case and control subjects (mother and infant). The Val105/Val105 genotype of GSTP1 occurred at a higher frequency than reported for other populations. Neither maternal nor fetal EPHX Tyr113His and GSTP1 Ile105Val polymorphisms appear to contribute significantly to the pathophysiology of pre-eclampsia in the Coloured population of the Western Cape region of South Africa.
Authors:
G S Gebhardt; W H M Peters; R Hillermann; H J Odendaal; K Carelse-Tofa; M T M Raijmakers; E A P Steegers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  24     ISSN:  0144-3615     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2005-09-08     Completed Date:  2005-09-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  866-72     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, University of Stellenbosch, South Africa. gsgeb@sun.ac.za
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group / genetics
Alleles
DNA / analysis
Epoxide Hydrolases / genetics*
Exons
Female
Fetus / enzymology*
Gene Frequency
Genotype
Glutathione Transferase / genetics*
Histidine
Humans
Polymorphism, Single Nucleotide / genetics*
Pre-Eclampsia / genetics*
Pregnancy
South Africa
Chemical
Reg. No./Substance:
71-00-1/Histidine; 9007-49-2/DNA; EC 2.5.1.18/Glutathione Transferase; EC 3.3.2.-/Epoxide Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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