| Maternal and fetal single nucleotide polymorphisms in the epoxide hydrolase and gluthatione S-transferase P1 genes are not associated with pre-eclampsia in the Coloured population of the Western Cape, South Africa. | |
| | |
MedLine Citation:
|
PMID: 16147638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Oxidative stress is thought to play an important role in the pathophysiology of pre-eclampsia. A defect in certain enzymes responsible for detoxification may cause prolonged exposure to reactive by-products and contribute to maternal endothelial as well as placental damage. Two polymorphisms affecting the function of the biotransformation enzymes epoxide hydrolase and glutathione S-transferase P1 were shown previously to be associated with pre-eclampsia in a Dutch population. The aim of this study was to determine if these two polymorphisms (maternal or fetal) contribute to pre-eclampsia in an anthropologically distinct population (the Western Cape region of South Africa) with a high incidence of the disease. Genomic DNA of mother - infant pairs with severe pre-eclampsia (n = 144), a population control group (n = 156) and control mother - infant pairs with uncomplicated pregnancy outcome (n = 45) were analysed for the EPHX and GSTP1 polymorphisms by polymerase chain reaction amplification and restriction enzyme digestion. Each polymorphism had a similar distribution in case and control subjects (mother and infant). The Val105/Val105 genotype of GSTP1 occurred at a higher frequency than reported for other populations. Neither maternal nor fetal EPHX Tyr113His and GSTP1 Ile105Val polymorphisms appear to contribute significantly to the pathophysiology of pre-eclampsia in the Coloured population of the Western Cape region of South Africa. |
| | |
Authors:
|
G S Gebhardt; W H M Peters; R Hillermann; H J Odendaal; K Carelse-Tofa; M T M Raijmakers; E A P Steegers |
Related Documents
:
|
18417548 - Calreticulin in human pregnancy and pre-eclampsia. 18029528 - Unsuspected 34-week pregnancy presenting as acute hypoxaemic respiratory failure. 11133008 - The expression and activity of monoamine oxidase a, but not of the serotonin transporte... 9033238 - Scientific basis for the content of routine antenatal care. i. philosophy, recent studi... 18359068 - Comparison of oocyte developmental competence and follicular steroid content of nullipa... 3925848 - Selection of agents for enhanced follicular recruitment in an in vitro fertilization an... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology Volume: 24 ISSN: 0144-3615 ISO Abbreviation: J Obstet Gynaecol Publication Date: 2004 Nov |
Date Detail:
|
Created Date: 2005-09-08 Completed Date: 2005-09-22 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 8309140 Medline TA: J Obstet Gynaecol Country: England |
Other Details:
|
Languages: eng Pagination: 866-72 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynaecology, University of Stellenbosch, South Africa. gsgeb@sun.ac.za |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
African Continental Ancestry Group
/
genetics Alleles DNA / analysis Epoxide Hydrolases / genetics* Exons Female Fetus / enzymology* Gene Frequency Genotype Glutathione Transferase / genetics* Histidine Humans Polymorphism, Single Nucleotide / genetics* Pre-Eclampsia / genetics* Pregnancy South Africa |
| Chemical | |
Reg. No./Substance:
|
71-00-1/Histidine; 9007-49-2/DNA; EC 2.5.1.18/Glutathione Transferase; EC 3.3.2.-/Epoxide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Midtrimester screening for microalbuminuria in healthy pregnant women.
Next Document: Use of proteomic patterns as a novel screening tool in pre-eclampsia.