| Maternal and fetal outcomes in pregnancy complicated with acute leukemia: a single institutional experience with 10 pregnancies at 16 years. | |
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MedLine Citation:
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PMID: 12620288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of acute leukemia in pregnancy is low and the management of acute leukemia during pregnancy is difficult. We have observed a total of 10 pregnancies in 8 patients. Six of the patients had acute myeloblastic leukemia (AML) and two of them had acute lymphoblastic leukemia (ALL). Three of the pregnancies were diagnosed when the leukemia was in remission, six at the time of leukemia diagnosis and one at the time of leukemic relapse. Six of the pregnancies were found in first trimester, three in the second and one early in the third. Three pregnancies ended with spontaneous abortion, three with intrauterine death and three with medical termination. One of spontaneous abortions and one intrauterine death developed during combination chemotherapy (daunorubicin, cytarabine). Only 1 healthy baby survived from the 10 pregnancies and this child was the not exposed to chemotherapeutic agents. None of the cases had gynecologic and obstetric complications. Five of eight pregnant women with leukemia died because of the primary disease. |
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Authors:
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Ridvan Ali; Fahir Ozkalemkaş; Tülay Ozçelik; Vildan Ozkocaman; Ulkü Ozan; Yalçin Kimya; Ahmet Tunali |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Leukemia research Volume: 27 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-03-06 Completed Date: 2003-04-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 381-5 Citation Subset: IM |
Affiliation:
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Division of Haematology, Department of Internal Medicine, Uludag University School of Medicine, Uludag University Hospital, Bursa, Turkey. ridvanali@uludag.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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epidemiology Abortion, Therapeutic Acute Disease Adult Antineoplastic Combined Chemotherapy Protocols / adverse effects, therapeutic use Cytarabine / administration & dosage Daunorubicin / administration & dosage Fatal Outcome Female Fetal Death / chemically induced, epidemiology Follow-Up Studies Gestational Age Humans Infant, Newborn Leukemia, Myeloid / epidemiology* Male Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology* Pregnancy Pregnancy Complications, Neoplastic / epidemiology* Pregnancy Outcome* Retrospective Studies Turkey / epidemiology |
| Chemical | |
Reg. No./Substance:
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147-94-4/Cytarabine; 20830-81-3/Daunorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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