Document Detail

Maternal-fetal n-6 and n-3 polyunsaturated fatty acids gradient in plasma and red cell phospholipids.
MedLine Citation:
PMID:  11725693     Owner:  NLM     Status:  MEDLINE    
Fatty acid distribution was investigated in ethnically and economically homogenous Korean mothers (n = 40) and neonates. Venous blood, maternal before delivery and cord, was obtained. Choline (CPG) and ethanolamine (EPG) phosphoglycerides and sphingomyelin (SM) were assayed. Mean arachidonic acid (AA) level was higher in plasma CPG and SM (p < 0.0001), and red cell CPG (p < 0.0001), EPG (p < 0.0001) and SM (p = 0.005) of the neonates. Similarly, the neonates had higher proportions of docosahexaenoic acid (DHA) in plasma CPG (p < 0.0001) and red cell CPG (p = 0.001) and EPG (p = 0.036). In contrast, linoleic and alpha-linolenic acids were significantly higher in maternal blood. Mead acid was elevated in plasma CPG (p < 0.0001) and red cell CPG and EPG (p < 0.0001) of the neonates. Consistent with data from high-fat-intake populations, our subjects, whose traditional diet is low in fat, exhibited maternal-fetal gradient in AA and DHA in plasma and red cell phospholipids. This may be due to an imbalance between supply and maternal and fetal requirements, and/or a physiological response to pregnancy. Prenatal nutritional constraint is associated with impaired development and a risk of chronic diseases in adults. AA and DHA are vital nutrients. Hence, there is a need to investigate whether the discrepancy between maternal and neonatal AA and DHA is a manifestation of nutritional insufficiency.
Y Min; K Ghebremeskel; M A Crawford; J H Nam; A Kim; I S Lee; H Suzuki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  71     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-11-29     Completed Date:  2002-05-22     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  286-92     Citation Subset:  IM    
Institute of Brain Chemistry and Human Nutrition, University of North London, London N7 8DB, UK.
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MeSH Terms
Antilipemic Agents / blood*
Erythrocytes / physiology*
Fatty Acids, Omega-3
Fatty Acids, Omega-6
Fatty Acids, Unsaturated / blood*
Infant, Newborn / blood
Korea / ethnology
Maternal-Fetal Exchange / physiology*
Phosphatidylcholines / blood
Phosphatidylethanolamines / blood
Phospholipids / blood*
Sphingomyelins / blood
Triglycerides / blood*
Reg. No./Substance:
0/Antilipemic Agents; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phospholipids; 0/Sphingomyelins; 0/Triglycerides; 100085-40-3/Pikasol

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