Document Detail


Maternal-fetal n-6 and n-3 polyunsaturated fatty acids gradient in plasma and red cell phospholipids.
MedLine Citation:
PMID:  11725693     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fatty acid distribution was investigated in ethnically and economically homogenous Korean mothers (n = 40) and neonates. Venous blood, maternal before delivery and cord, was obtained. Choline (CPG) and ethanolamine (EPG) phosphoglycerides and sphingomyelin (SM) were assayed. Mean arachidonic acid (AA) level was higher in plasma CPG and SM (p < 0.0001), and red cell CPG (p < 0.0001), EPG (p < 0.0001) and SM (p = 0.005) of the neonates. Similarly, the neonates had higher proportions of docosahexaenoic acid (DHA) in plasma CPG (p < 0.0001) and red cell CPG (p = 0.001) and EPG (p = 0.036). In contrast, linoleic and alpha-linolenic acids were significantly higher in maternal blood. Mead acid was elevated in plasma CPG (p < 0.0001) and red cell CPG and EPG (p < 0.0001) of the neonates. Consistent with data from high-fat-intake populations, our subjects, whose traditional diet is low in fat, exhibited maternal-fetal gradient in AA and DHA in plasma and red cell phospholipids. This may be due to an imbalance between supply and maternal and fetal requirements, and/or a physiological response to pregnancy. Prenatal nutritional constraint is associated with impaired development and a risk of chronic diseases in adults. AA and DHA are vital nutrients. Hence, there is a need to investigate whether the discrepancy between maternal and neonatal AA and DHA is a manifestation of nutritional insufficiency.
Authors:
Y Min; K Ghebremeskel; M A Crawford; J H Nam; A Kim; I S Lee; H Suzuki
Related Documents :
15830643 - Individual and combined effects of selective cyclooxygenase-2 inhibitor and omega-3 fat...
20737653 - Simultaneous quantification of total eicosapentaenoic acid, docosahexaenoic acid and ar...
11764403 - Determination of diamino acids in peptidoglycans from anaerobic bacteria.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  71     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-11-29     Completed Date:  2002-05-22     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  286-92     Citation Subset:  IM    
Affiliation:
Institute of Brain Chemistry and Human Nutrition, University of North London, London N7 8DB, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Antilipemic Agents / blood*
Erythrocytes / physiology*
Fatty Acids, Omega-3
Fatty Acids, Omega-6
Fatty Acids, Unsaturated / blood*
Female
Humans
Infant, Newborn / blood
Korea / ethnology
Maternal-Fetal Exchange / physiology*
Phosphatidylcholines / blood
Phosphatidylethanolamines / blood
Phospholipids / blood*
Pregnancy
Sphingomyelins / blood
Triglycerides / blood*
Chemical
Reg. No./Substance:
0/Antilipemic Agents; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phospholipids; 0/Sphingomyelins; 0/Triglycerides; 100085-40-3/Pikasol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nutritional and food protection against epidemic emerging neuropathy. Epidemiological findings in th...
Next Document:  Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-y...