Document Detail


Maternal and fetal levels of propofol at caesarean section.
MedLine Citation:
PMID:  2368890     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty women were given a bolus induction of propofol 2.0 mg.kg-1 for elective caesarean section. Induction to delivery times ranged from five to fourteen minutes. At delivery the maternal venous (MV) concentrations of propofol ranged from 0.53 to 1.48 micrograms.ml-1 umbilical vein (UV) 0.39 to 1.4 micrograms.ml-1 and umbilical artery (UA) 0.34 to 0.68 micrograms.ml-1 MV propofol concentrations were always higher than corresponding UV concentrations. The mean (95% confidence interval) UV/MV ratio was 0.65 (0.56-0.74) and the mean UA/UV ratio was 1.07 (0.99-1.15). Neither ratio was shown to be correlated with induction to delivery time. Distribution of propofol is rapid across the placenta and in the fetus. Apgar scores were higher with shorter incision to delivery times but were not correlated to umbilical levels of propofol.
Authors:
T Gin; M A Gregory; K Chan; T E Oh
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  18     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  180-4     Citation Subset:  IM    
Affiliation:
Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, Shatin, N.T., Hong Kong.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anesthesia, Intravenous*
Anesthesia, Obstetrical*
Apgar Score
Cesarean Section*
Chromatography, High Pressure Liquid
Delivery, Obstetric
Female
Fetal Blood / analysis*
Humans
Infant, Newborn
Maternal-Fetal Exchange*
Placenta / metabolism
Pregnancy
Propofol / blood*
Time Factors
Chemical
Reg. No./Substance:
2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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