Document Detail

Maternal and fetal insulin-like growth factors and their binding proteins in the second and third trimesters of human pregnancy.
MedLine Citation:
PMID:  9647578     Owner:  NLM     Status:  MEDLINE    
The insulin-like growth factors (IGFs) are mitogenic polypeptides which circulate bound to a series of at least six binding proteins (IGFBPs). An increasing body of evidence supports a major role for the IGF in the control of human fetal growth although normal values in the human fetal circulation have not been established. In order to provide an accurate reflection of fetal IGFs and IGFBPs in utero, we have sampled fetal blood direct from the umbilical cord at 18-38 weeks of gestation using the technique of cordocentesis. We have measured IGF-I, IGF-II and IGFBP 1-3 in 91 fetuses in order to establish concentrations for these parameters in the second and third trimesters of human pregnancy.
K Langford; K Nicolaides; J P Miell
Related Documents :
9259708 - Fetal growth is associated positively with maternal intake of riboflavin and negatively...
911668 - Coxsackievirus b3 infection in pregnancy and its influence on foetal heart development.
1913818 - Genetic analysis of growth cone guidance in drosophila: fasciclin ii functions as a neu...
8490088 - Fetal size and growth.
25066688 - Rubella and pregnancy: diagnosis, management and outcomes.
23143408 - Does mode of delivery affect neonate oxidative stress in parturition? review of literat...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  13     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-09-21     Completed Date:  1998-09-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1389-93     Citation Subset:  IM    
Department of Medicine, King's College School of Medicine, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Fetal Blood / metabolism*
Gestational Age
Insulin-Like Growth Factor Binding Protein 1 / blood
Insulin-Like Growth Factor Binding Protein 2 / blood
Insulin-Like Growth Factor Binding Protein 3 / blood
Insulin-Like Growth Factor Binding Proteins / blood*
Insulin-Like Growth Factor I / metabolism
Insulin-Like Growth Factor II / metabolism
Pregnancy / blood*
Reference Values
Somatomedins / metabolism*
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Protein 1; 0/Insulin-Like Growth Factor Binding Protein 2; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Insulin-Like Growth Factor Binding Proteins; 0/Somatomedins; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Successful pregnancy outcome following Tompkins metroplasty done early in pregnancy.
Next Document:  Trends in male:female ratio among newborn infants in 29 countries from five continents.