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Maternal and fetal haemodynamic effects of nifedipine in normotensive pregnant women.
MedLine Citation:
PMID:  21219592     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Please cite this paper as: Cornette J, Duvekot J, Roos-Hesselink J, Hop W, Steegers E. Maternal and fetal haemodynamic effects of nifedipine in normotensive pregnant women. BJOG 2010; DOI: 10.1111/j.1471-0528.2010.02794.x. While nifedipine is commonly used for tocolysis, the controversy on its safety remains. So far, the haemodynamic effects on maternal and fetal circulations have not been well documented. Fifteen normotensive women who received 20 mg nifedipine were included in this prospective observational study. The maternal and fetal haemodynamic effects were analysed using maternal echocardiography and fetal Doppler ultrasonography. Nifedipine induced a significant afterload reduction in all women. It triggered a compensatory increase in cardiac output, which maintained blood pressure. These maternal changes had no influence on the uteroplacental and fetal circulations.
Authors:
J Cornette; Jj Duvekot; Jw Roos-Hesselink; Wcj Hop; Eap Steegers
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-24
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  -     ISSN:  1471-0528     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-1-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology.
Affiliation:
Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology Department of Cardiology Department of Biostatistics, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands.
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