Document Detail

Maternal and fetal exposure to pesticides associated to genetically modified foods in Eastern Townships of Quebec, Canada.
MedLine Citation:
PMID:  21338670     Owner:  NLM     Status:  MEDLINE    
Pesticides associated to genetically modified foods (PAGMF), are engineered to tolerate herbicides such as glyphosate (GLYP) and gluphosinate (GLUF) or insecticides such as the bacterial toxin bacillus thuringiensis (Bt). The aim of this study was to evaluate the correlation between maternal and fetal exposure, and to determine exposure levels of GLYP and its metabolite aminomethyl phosphoric acid (AMPA), GLUF and its metabolite 3-methylphosphinicopropionic acid (3-MPPA) and Cry1Ab protein (a Bt toxin) in Eastern Townships of Quebec, Canada. Blood of thirty pregnant women (PW) and thirty-nine nonpregnant women (NPW) were studied. Serum GLYP and GLUF were detected in NPW and not detected in PW. Serum 3-MPPA and CryAb1 toxin were detected in PW, their fetuses and NPW. This is the first study to reveal the presence of circulating PAGMF in women with and without pregnancy, paving the way for a new field in reproductive toxicology including nutrition and utero-placental toxicities.
Aziz Aris; Samuel Leblanc
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-18
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  31     ISSN:  1873-1708     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-27     Completed Date:  2011-09-20     Revised Date:  2012-05-22    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  528-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Obstetrics and Gynecology, University of Sherbrooke Hospital Centre, Sherbrooke, Quebec, Canada.
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MeSH Terms
Aminobutyric Acids / adverse effects,  blood,  pharmacokinetics*
Bacterial Proteins / blood
Endotoxins / blood
Fetal Blood / metabolism*
Food, Genetically Modified*
Gas Chromatography-Mass Spectrometry
Glycine / adverse effects,  analogs & derivatives*,  blood,  pharmacokinetics
Hemolysin Proteins / blood
Infant, Newborn
Maternal Exposure*
Maternal-Fetal Exchange
Organophosphorus Compounds / blood
Pesticides / adverse effects,  blood,  pharmacokinetics*
Phosphoric Acids / blood
Propionic Acids / blood
Reg. No./Substance:
0/Aminobutyric Acids; 0/Bacterial Proteins; 0/Endotoxins; 0/Hemolysin Proteins; 0/Organophosphorus Compounds; 0/Pesticides; 0/Phosphoric Acids; 0/Propionic Acids; 0/insecticidal crystal protein, Bacillus Thuringiensis; 0/methylphosphinicopropionic acid; 1071-83-6/glyphosate; 51276-47-2/phosphinothricin; 56-40-6/Glycine; 7664-38-2/phosphoric acid
Comment In:
Reprod Toxicol. 2012 Jun;33(3):401-2; author reply 403-4   [PMID:  22382376 ]
Reprod Toxicol. 2011 Dec;32(4):494-5; author reply 496-7   [PMID:  22001252 ]
Reprod Toxicol. 2012 Jan;33(1):120-1; author reply 122-3   [PMID:  22074695 ]

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