Document Detail

Maternal and fetal epoxyeicosatrienoic acids in normotensive and preeclamptic pregnancies.
MedLine Citation:
PMID:  23382413     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) are cytochrome P450 metabolites of arachidonic acid posited to act in the circulatory adaptation to pregnancy and the development of preeclampsia. Red blood cells (RBCs) may function as major contributors of cis- and trans-EETs.
METHODS: We performed paired analyses of EETs, dihydroxyeicosatrienoic acids (DHETs), and 20-HETE in RBCs, plasma, and urine from preeclamptic and normotensive pregnant and nonpregnant women. Blood from fetal and maternal circulation was collected. EETs, DHETs, and 20-HETE were analyzed by gas chromatography and liquid chromatography mass spectrometry. Vascular function and inflammation indices were analyzed.
RESULTS: Plasma EET is higher in normotensive (median, range; 9.9, 6.3-25.2ng/mL n = 29) and preeclamptic (10.9, 6.0-48.0ng/mL, n = 19) women than in nonpregnant controls (7.3, 3.7-10.2ng/mL, n = 19) and correlate with RBC EETs, C-reactive protein, and arterial stiffness. Renal production of EETs, measured as urinary DHETs, was reduced in preeclamptic (4.5, 1.6-24.5ng/mg creatinine) compared to normotensive (11.4, 1.6-44.5ng/mg creatinine) pregnancies. EETs are 3- to 5-fold greater in fetoplacental than in maternal circulation (RBCs 36.6, 13.1-69.4 vs. 12.5, 6.4-12.0ng/10(9) cells; plasma 31.6, 8.5-192.6 vs. 12.0, 6.8-48.0ng/mL). Both cis- and trans-EETs are present in fetal RBCs.
CONCLUSIONS: RBCs contribute to elevated levels of EETs in the fetoplacental circulation. EETs may modulate systemic and fetoplacental hemodynamics in normal and preeclamptic pregnancies. Decreased renal EET generation may be associated with the development of maternal renal dysfunction and hypertension in preeclampsia.
Houli Jiang; John C McGiff; Cristiano Fava; Gabriella Amen; Elisa Nesta; Giovanni Zanconato; John Quilley; Pietro Minuz
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-12-28
Journal Detail:
Title:  American journal of hypertension     Volume:  26     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-08-30     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-8     Citation Subset:  IM    
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MeSH Terms
C-Reactive Protein / metabolism
Cross-Sectional Studies
Eicosanoids / metabolism*
Erythrocytes / physiology
Fetus / metabolism*
Hemodynamics / physiology
Hydroxyeicosatetraenoic Acids / metabolism
Infant, Newborn / metabolism*
Middle Aged
Pre-Eclampsia / metabolism*,  physiopathology
Pregnancy / metabolism*
Pregnancy Complications, Cardiovascular / metabolism*,  physiopathology
Pregnancy Trimester, Second / metabolism
Pregnancy Trimester, Third / metabolism
Vascular Stiffness / physiology
Grant Support
Reg. No./Substance:
0/Eicosanoids; 0/Hydroxyeicosatetraenoic Acids; 79551-86-3/20-hydroxy-5,8,11,14-eicosatetraenoic acid; 9007-41-4/C-Reactive Protein

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