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Maternal-fetal epigenetic interactions in the beginning of cardiovascular damage.
MedLine Citation:
PMID:  21764886     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Several studies indicate that impaired fetal growth, and in utero exposure to risk factors, especially maternal hypercholesterolemia, may be relevant for the early onset of cardiovascular damage. The exact molecular mechanisms of such fetal programming are still unclear. Epigenetics may represent one of the possible scientific explanations of the impact of such intrauterine risk factors for the subsequent development of cardiovascular disease (CVD) during adult age. Translational studies support this hypothesis, however a direct causality in humans cannot be ascertained. This task could be investigated in primates and in human post-mortem fetal arteries. Importantly, some studies also suggest the transgenerational transmission of epigenetic risk. The recently launched International Human Epigenome Consortium and the NIH Roadmap Epigenomics Mapping Consortium will provide the rationale for a useful clinical scenario for primary prevention and therapy CVD. Despite the heritable nature of epigenetic modification, the clinically relevant information is that it could be reversible through therapeutic approaches including histone deacetylase inhibitors, histone acetyltransferase inhibitors and commonly used drugs such as statins.
Authors:
Claudio Napoli; Teresa Infante; Amelia Casamassimi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-15
Journal Detail:
Title:  Cardiovascular research     Volume:  -     ISSN:  1755-3245     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of General Pathology, Division of Clinical Pathology and Excellence Research Centre on Cardiovascular Disease, U.O.C. Division of Immunohematology and Transplantation-CRT, 1 School of Medicine, Second University of Naples, 80138 Naples, Italy.
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