Document Detail

Maternal and fetal effects of intravenous patient-controlled fentanyl analgesia during labour in a thrombocytopenic parturient.
MedLine Citation:
PMID:  1551160     Owner:  NLM     Status:  MEDLINE    
The use of intravenous (i.v.) patient-controlled fentanyl analgesia during labour in a parturient with unexplained thrombocytopenia (70 x 10(3).ml-1) is described. The patient self-administered boluses of 25 micrograms of fentanyl with a lock-out interval of ten min. In addition, a concurrent fentanyl infusion of 25 was given. Effective analgesia was achieved during labour and a total of 1025 micrograms of fentanyl was infused over 11 hr 55 min until delivery of a vigorous infant with Apgar scores of 9 after one and five min. Respiratory depression or undue sedation were not observed in the mother either during labour or in the post-partum period. At birth, maternal total plasma fentanyl concentration was 1.11, whereas neonatal umbilical total plasma fentanyl concentration was 0.43 Newborn plasma protein binding of fentanyl was lower compared to the mother (63% vs 89%). Thus, free fentanyl concentrations (0.16 were identical in the mother and newborn at delivery.
O P Rosaeg; J B Kitts; G Koren; L J Byford
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  39     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-30     Completed Date:  1992-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  277-81     Citation Subset:  IM    
Department of Anaesthesia, Ottawa Civic Hospital, University of Ottawa, Ontario.
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MeSH Terms
Analgesia, Obstetrical*
Analgesia, Patient-Controlled*
Fentanyl / administration & dosage,  blood,  pharmacology*
Fetal Blood / chemistry
Infant, Newborn
Injections, Intravenous
Labor, Obstetric*
Maternal-Fetal Exchange*
Pregnancy Complications / physiopathology*
Protein Binding
Thrombocytopenia / physiopathology*
Reg. No./Substance:
Comment In:
Can J Anaesth. 1992 Dec;39(10):1116-7   [PMID:  1298246 ]

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