Document Detail


Maternal and fetal effects of intravenous patient-controlled fentanyl analgesia during labour in a thrombocytopenic parturient.
MedLine Citation:
PMID:  1551160     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of intravenous (i.v.) patient-controlled fentanyl analgesia during labour in a parturient with unexplained thrombocytopenia (70 x 10(3).ml-1) is described. The patient self-administered boluses of 25 micrograms of fentanyl with a lock-out interval of ten min. In addition, a concurrent fentanyl infusion of 25 micrograms.hr-1 was given. Effective analgesia was achieved during labour and a total of 1025 micrograms of fentanyl was infused over 11 hr 55 min until delivery of a vigorous infant with Apgar scores of 9 after one and five min. Respiratory depression or undue sedation were not observed in the mother either during labour or in the post-partum period. At birth, maternal total plasma fentanyl concentration was 1.11 ng.ml-1, whereas neonatal umbilical total plasma fentanyl concentration was 0.43 ng.ml-1. Newborn plasma protein binding of fentanyl was lower compared to the mother (63% vs 89%). Thus, free fentanyl concentrations (0.16 ng.ml-1) were identical in the mother and newborn at delivery.
Authors:
O P Rosaeg; J B Kitts; G Koren; L J Byford
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  39     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-30     Completed Date:  1992-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  277-81     Citation Subset:  IM    
Affiliation:
Department of Anaesthesia, Ottawa Civic Hospital, University of Ottawa, Ontario.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analgesia, Obstetrical*
Analgesia, Patient-Controlled*
Female
Fentanyl / administration & dosage,  blood,  pharmacology*
Fetal Blood / chemistry
Humans
Infant, Newborn
Injections, Intravenous
Labor, Obstetric*
Maternal-Fetal Exchange*
Pregnancy
Pregnancy Complications / physiopathology*
Protein Binding
Thrombocytopenia / physiopathology*
Chemical
Reg. No./Substance:
437-38-7/Fentanyl
Comments/Corrections
Comment In:
Can J Anaesth. 1992 Dec;39(10):1116-7   [PMID:  1298246 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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