Document Detail


Maternal-fetal distribution of manganese in the rat following inhalation exposure to manganese sulfate.
MedLine Citation:
PMID:  16112325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies examining the pharmacokinetics of manganese during pregnancy have largely focused on the oral route of exposure and have shown that the amount of manganese that crosses the rodent placenta is low. However, limited information exists regarding the distribution of manganese in fetal tissues following inhalation. The objective of this study was to determine manganese body burden in CD rats and fetuses following inhalation of a MnSO4 aerosol during pregnancy. Animals were evaluated following pre-breeding (2 weeks), mating (up to 14 days) and gestational (from gestation day (GD) 0 though 20) exposure to air or MnSO4 (0.05, 0.5, or 1 mg Mn/m(3)) for 6h/day, 7 days/week. The following maternal samples were collected for manganese analysis: whole blood, lung, pancreas, liver, brain, femur, and placenta. Fetal tissues were examined on GD 20 and included whole blood, lung, liver, brain, and skull cap. Maternal lung manganese concentrations were increased following exposure to MnSO4 at >or=0.05 mg Mn/m(3). Maternal brain and placenta manganese concentrations were increased following exposure of pregnant rats to MnSO4 at >or=0.5 mg Mn/m(3). Increased fetal liver manganese concentrations were observed following in utero exposure to MnSO4 at >or=0.5 mg Mn/m(3). Manganese concentrations within all other fetal tissues were not different from air-exposed controls. The results of this study demonstrate that the placenta partially sequesters inhaled manganese, thereby limiting exposure to the fetus.
Authors:
David C Dorman; Anna M McElveen; Marianne W Marshall; Carl U Parkinson; R Arden James; Melanie F Struve; Brian A Wong
Related Documents :
3755915 - Maturity of fetal lungs determined by bubble stability in amniotic fluid.
19122105 - Ureaplasma parvum or mycoplasma hominis as sole pathogens cause chorioamnionitis, prete...
16727795 - Isolation of mycoplasma mycoides, mycoides (lc variant), from two naturally aborted cap...
17880415 - Lung function and bronchial hyper-responsiveness 11 years after hospitalization for bro...
20444015 - Transplacental exchange of moxidectin after maternal or fetal intravenous administratio...
9414435 - Identification of early pregnancy factor as chaperonin 10: implications for understandi...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurotoxicology     Volume:  26     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-22     Completed Date:  2005-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  625-32     Citation Subset:  IM    
Affiliation:
CIIT Centers for Health Research, 6 Davis Drive, P.O. Box 12137, Research Triangle Park, NC 27709-2137, USA. dorman@ciit.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Burden
Female
Fetus / metabolism*
Inhalation Exposure
Male
Manganese Compounds / administration & dosage,  pharmacokinetics*
Maternal-Fetal Exchange / physiology*
Organ Size / drug effects
Pregnancy
Rats
Sulfates / administration & dosage,  pharmacokinetics*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Manganese Compounds; 0/Sulfates; 7785-87-7/manganese sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neurobehavioral performance in preschool children from agricultural and non-agricultural communities...
Next Document:  Neurological impairment in fetal mouse brain by drinking water disinfectant byproducts.