Document Detail


Maternal and fetal circulation of unusual bile acids: a pilot study.
MedLine Citation:
PMID:  21810147     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Large amounts of unusual bile acids are synthesized by the fetal liver in late gestation. These compounds mostly are transferred from fetus to mother, though some are excreted into the amniotic fluid. We investigated the role of placental transfer of bile acids in fetal bile acid metabolism, particularly with respect to the unusual bile acids (1β-hydroxylated and ketonic bile acids). Methods:  We measured concentrations of bile acids in umbilical cord blood and urine of newborn infants, and in perinatal maternal serum and urine, using gas chromatography-mass spectrometry. Serum and urine specimens from healthy nonpregnant women were used as controls. Results:  In newborn infants at delivery, cord blood and urine contained mostly primary and 1β-hydroxylated bile acids, respectively. We also detected large amounts of ketonic bile acids in their urine, and the urinary concentration of total bile acids was elevated. Main maternal bile acids at 30 and 35 weeks of gestation and at delivery were 1β-hydroxylated bile acids. After delivery, main bile acids changed from 1β-hydroxylated bile acids to primary bile acids (p<0.03), which also predominated in healthy nonpregnant woman. Conclusion:  Fetally synthesized unusual bile acids were transported from fetus to mother. Pregnant women appear to excrete these bile acids into the urine, lowering both fetal and maternal serum bile acid concentrations.
Authors:
Yoshitaka Seki; Masami Matsushita; Akihiko Kimura; Hiroshi Nishiura; Kumiko Aoki; Takahiro Inokuchi; Tatsuki Mizuochi; Takao Kurosawa; Yukuo Kimura; Toyojiro Matsuishi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-2
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society.
Affiliation:
Department of Pediatrics and Child Health, and Research Institute of Medical Mass Spectrometry, Kurume University School of Medicine, Kurume; Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido; and Kimura Kaisei Obstetrics and Gynecology Clinic, Yanagawa, Japan.
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