Document Detail

Maternal and fetal cadmium and selenium status in normotensive and hypertensive pregnancy.
MedLine Citation:
PMID:  12449233     Owner:  NLM     Status:  MEDLINE    
Cadmium and selenium concentrations in maternal and umbilical cord blood and amniotic fluid were determined in 37 normotensive and 23 hypertensive women during the last trimester of pregnancy in relation to their smoking status. Thiocyanate concentration in plasma was used as the index of smoking status. Cadmium and selenium were determined with atomic absorption spectrometry (graphite furnace and mercury hydride system). In the group of normotensive and hypertensive women, significantly higher cadmium and lower selenium concentrations in blood in smokers were observed than in nonsmokers. Umbilical cord blood selenium concentrations in both normotensive and hypertensive smokers were significantly lower than in nonsmokers as well. In the group of normotensive women, significant differences in selenium concentrations in amniotic fluid were observed between smokers and non-smokers. In conclusion, the results of this study show that hypertension in pregnant women smokers is related to significantly higher blood cadmium concentrations, which indicates that cadmium may be considered as an independent factor involved in hypertension.
Melita Kosanovic; Milan Jokanovic; Milan Jevremovic; Silva Dobric; Dubravko Bokonjic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological trace element research     Volume:  89     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-25     Completed Date:  2003-11-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  97-103     Citation Subset:  IM    
Faculty of Medicine, UAE Univeristy, Al Ain, United Arab Emirates.
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MeSH Terms
Amniotic Fluid / chemistry
Blood Pressure / physiology*
Cadmium / analysis,  blood*
Fetal Blood / chemistry*
Hypertension / blood*
Maternal-Fetal Exchange / physiology
Placenta / chemistry
Pregnancy Trimester, Third / blood*
Selenium / analysis,  blood*
Smoking / blood*
Thiocyanates / blood
Reg. No./Substance:
0/Thiocyanates; 302-04-5/thiocyanate; 7440-43-9/Cadmium; 7782-49-2/Selenium

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