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Maternal and fetal blood levels of moxifloxacin, levofloxacin, cefepime and cefoperazone.
MedLine Citation:
PMID:  20418070     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Wide-spectrum quinolones such as moxifloxacin and levofloxacin as well as high-order cephalosporins such as cefoperazone and cefepime have increased antimicrobial activity. However, little is known about their distribution in fetal blood. Therefore, the aim of this study was to measure and compare maternal and fetal blood levels of these agents. For the measurement of blood levels, 9 pregnant women received cefepime hydrochloride, 10 received cefoperazone, 10 received moxifloxacin and 12 received levofloxacin intravenously. Maternal and umbilical cord blood samples were drawn during delivery. Antibiotic levels were analysed by high-performance liquid chromatography. Mean transplacental passage rates of moxifloxacin, levofloxacin, cefepime and cefoperazone were 74.84%, 66.53%, 23.21% and 12.68%, respectively, and mean transfetal passage rates were 90.78%, 84.22%, 79.17% and 79.78%, respectively. The transplacental passage rate for either quinolone was significantly higher than that of either cephalosporin, and the transplacental passage rate of cefoperazone was lower than that of cefepime. In conclusion, both quinolones have high transplacental passage rates. Cefepime and cefoperazone have a lower transplacental passage rate and thus may be used as prophylaxis in situations where transplacental passage is undesirable.
Authors:
Ozgur Ozyuncu; Emirhan Nemutlu; Doruk Katlan; Sedef Kir; M Sinan Beksac
Publication Detail:
Type:  Journal Article     Date:  2010-04-24
Journal Detail:
Title:  International journal of antimicrobial agents     Volume:  36     ISSN:  1872-7913     ISO Abbreviation:  Int. J. Antimicrob. Agents     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111860     Medline TA:  Int J Antimicrob Agents     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  175-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Affiliation:
Faculty of Medicine, Department of Obstetrics and Gynecology, Maternal Fetal Medicine and Perinatology Unit, Hacettepe University, Sihhiye, Ankara, Turkey. ozyuncu@hacettepe.edu.tr
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