Document Detail


Maternal and fetal antibrain antibodies in development and disease.
MedLine Citation:
PMID:  22911883     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent evidence has emerged indicating that the maternal immune response can have a substantial deleterious impact on prenatal development (Croen et al., [2008]: Biol Psychiatry 64:583-588). The maternal immune response is largely sequestered from the fetus. Maternal antibodies, specifically immunoglobulin G (IgG), are passed to the fetus to provide passive immunity throughout much of pregnancy. However, both protective and pathogenic autoantibodies have equal access to the fetus (Goines and Van de Water [2010]: Curr Opin Neurol 23:111-117). If the mother has an underlying autoimmune disease or has reactivity to fetal antigens, autoantibodies produced before or during pregnancy can target tissues in the developing fetus. One such tissue is the fetal brain. The blood brainbarrier (BBB) is developing during the fetal period allowing maternal antibodies to have direct access to the brain during gestation (Diamond et al. [2009]: Nat Rev Immunol; Braunschweig et al. [2011]; Neurotoxicology 29:226-231). It has been proposed that brain injury by circulating brain-specific maternal autoantibodies might underlie multiple congenital, developmental disorders (Lee et al. [2009]: Nat Med 15:91-96). In this review, we will discuss the current state of research in the area of maternal autoantibodies and the development of autism.
Authors:
Elizabeth Fox; David Amaral; Judy Van de Water
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-09-04
Journal Detail:
Title:  Developmental neurobiology     Volume:  72     ISSN:  1932-846X     ISO Abbreviation:  Dev Neurobiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-06     Completed Date:  2013-04-10     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  101300215     Medline TA:  Dev Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1327-34     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Internal Medicine, University of California, Davis, Davis, California 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autistic Disorder / immunology*
Autoantibodies / adverse effects*,  immunology
Brain / embryology*,  immunology*
Female
Fetus / immunology
Humans
Maternal-Fetal Exchange / immunology
Pregnancy
Grant Support
ID/Acronym/Agency:
1 P01 ES11269-01/ES/NIEHS NIH HHS; P01 ES011269/ES/NIEHS NIH HHS; R01MH80218/MH/NIMH NIH HHS; RR00169/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Autoantibodies
Comments/Corrections

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