| Maternal-fetal HLA-DR relationships and pregnancy-induced hypertension. | |
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MedLine Citation:
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PMID: 1448243 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Some studies have found an increased prevalence of pregnancy-induced hypertension among women sharing HLA antigens with their spouses or fetuses, thus supporting the hypothesis that maternal sensitization to fetal HLA alloantigens reduces the risk for pregnancy-induced hypertension. However, not all studies have confirmed these findings. No investigators have examined the four different types of maternal-fetal HLA relationships in their studies of pregnancy-induced hypertension. Our goal was to examine such associations to test further the HLA-allosensitization hypothesis. METHODS: We conducted a cohort study of pregnancy-induced hypertension among 683 nulliparous women. Women and their neonates were typed for HLA-A, -B, -DR, and -DQ antigens using serologic techniques to establish maternal-fetal relationships. RESULTS: We found an increased prevalence of pregnancy-induced hypertension when the fetus, but not the mother, was potentially exposed to HLA-DR alloantigens (maternal allogenicity) compared with the other three conditions combined (P < .003). Controlling for confounding factors, the increased prevalence of pregnancy-induced hypertension persisted in situations of maternal HLA-DR allogenicity (P < .007). CONCLUSIONS: Based upon our observations and other immunologic studies of pregnancy-induced hypertensive and uncomplicated pregnancies, we conclude that a maternal humoral response against fetal anti-HLA-DR immunoglobulin (IgG) antibody may influence the development of pregnancy-induced hypertension. This could occur when an immunocompetent fetus is exposed to maternal HLA-DR alloantigens, maternal exposure to fetal HLA-DR alloantigens alloantigens, maternal exposure to fetal HLA-DR alloantigens is not possible, and fetal IgG antibody bears paternally inherited markers allogeneic to the mother. |
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Authors:
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C Hoff; K Peevy; K Giattina; J A Spinnato; R D Peterson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 80 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1992-12-24 Completed Date: 1992-12-24 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1007-12 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, College of Medicine, University of South Alabama, Mobile. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Eclampsia
/
blood,
epidemiology,
immunology* Female Fetal Blood / immunology* HLA-A Antigens / blood HLA-B Antigens / blood HLA-DQ Antigens / blood HLA-DR Antigens / blood* Humans Infant, Newborn Pre-Eclampsia / blood, epidemiology, immunology Pregnancy Prevalence |
| Grant Support | |
ID/Acronym/Agency:
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HD21144/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-DQ Antigens; 0/HLA-DR Antigens |
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