Document Detail


Maternal features of obstetric cholestasis: 20 years experience at King George V Hospital.
MedLine Citation:
PMID:  3233079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Between 1965 and 1984, 139 pregnancies in 125 women were complicated by obstetric cholestasis (OC). Prevalence increased from 0.1% in the first 10-year period to 0.2% in the second (p less than 0.001), following recognition of the adverse fetal risks of this condition. Perinatal data from both series, 1965-1974 and 1975-1984 have previously been published. Mothers in the latter series were more likely to be of Anglosaxon than Mediterranean origin (p less than 0.001) and did not have underlying haemolytic conditions. Diagnostic criteria changed considerably over the 20 years, such that liver biopsy was no longer needed, gastroenterological consultation was sought less frequently (p less than 0.001) and newer diagnostic criteria of increased bile acids with negative hepatitis serology were increasingly employed. Biochemical data were broadly similar in the 2 groups. An understanding of the clinical and laboratory features of this disease facilitates early diagnosis, which is imperative if intensive fetal surveillance is to reduce the high stillbirth rate in OC.
Authors:
N M Fisk; W B Bye; G N Storey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  28     ISSN:  0004-8666     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1989-04-14     Completed Date:  1989-04-14     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  172-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, King George V Memorial Hospital, Sydney, New South Wales.
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / blood
Alkaline Phosphatase / blood
Aspartate Aminotransferases / blood
Australia
Bilirubin / blood
Cholestasis, Intrahepatic / epidemiology*
Cholestyramine Resin / therapeutic use
Female
Humans
Pregnancy
Pregnancy Complications, Hematologic / epidemiology*
Pruritus / drug therapy
Chemical
Reg. No./Substance:
11041-12-6/Cholestyramine Resin; 635-65-4/Bilirubin; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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