Document Detail


Maternal exposure to procymidone has no effects on fetal external genitalia development in male rabbit fetuses in a modified developmental toxicity study.
MedLine Citation:
PMID:  20519838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was conducted to evaluate the effects of procymidone (PCM) on development of male rabbit fetal external genitalia. PCM was administered once daily by gavage at dose levels of 0 (control) and 125mg/kg/day to pregnant rabbits from gestation day 6 through 28 and fetal external genitalia was observed in detail. This treatment period covered the critical stage of sexual differentiation of fetal external genitalia in rabbits. In the maternal animals, food consumption was reduced in the PCM group. There were no effects of PCM on maternal caesarean sectioning data or fetal external observations. In fetal external genitalia observations, there were no significant differences between the control and PCM treatment group in any of the following parameters: ano-genital distance (AGD), phallus boundary-genital distance, diameter of preputial lamella, ventral gap of preputial lamella, or ventral gap to diameter ration of preputial lamella, though severe feminization such as decreasing of AGD and hypospadias in male rat offspring at the dose level of 125 mg/kg of PCM were reported. These results suggest that PCM has no effect on fetal external genitalia development in male rabbit fetuses, and species difference of developmental effects of PCM on sexual differentiation exists.
Authors:
Kunifumi Inawaka; Noriyuki Kishimoto; Hashihiro Higuchi; Satoshi Kawamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of toxicological sciences     Volume:  35     ISSN:  1880-3989     ISO Abbreviation:  J Toxicol Sci     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-03     Completed Date:  2010-09-23     Revised Date:  2011-07-21    
Medline Journal Info:
Nlm Unique ID:  7805798     Medline TA:  J Toxicol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  299-307     Citation Subset:  IM    
Affiliation:
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd. nawaka@sc.sumitomo-chem.co.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Bicyclo Compounds / administration & dosage,  toxicity*
Dose-Response Relationship, Drug
Female
Fungicides, Industrial / toxicity*
Genitalia, Male / drug effects*,  embryology*
Male
Maternal Exposure / adverse effects*
Maternal-Fetal Exchange*
Pregnancy
Rabbits
Rats
Sex Differentiation / drug effects
Species Specificity
Toxicity Tests / methods
Chemical
Reg. No./Substance:
0/Bicyclo Compounds; 0/Fungicides, Industrial; 32809-16-8/procymidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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