| Maternal exposure to low-level heavy metals during pregnancy and birth size. | |
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MedLine Citation:
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PMID: 20694885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the effect of environmental, low-level exposure to heavy metals during pregnancy, as estimated by urine analysis, on birth size of the newborns. Spot urine samples were collected from unexposed 78 pregnant women in Tokyo during 2007 and 2008. The urinary concentrations of beryllium (Be), copper (Cu), arsenic (As), zinc (Zn), selenium (Se), molybdenum (Mo), cadmium (Cd), tin (Sn), antimony (Sb), and lead (Pb) were measured by ICP-MS. The birthweight (BW), length (BL) and head circumference (HC) of the newborns delivered to the subjects were measured and relationship with urinary metal concentration was examined. The geometric mean concentration of urinary Be, Cu, As, Zn, Se, Mo, Cd, Sn, Sb, and Pb were 0.031, 12.8, 393, 76.9, 37.6, 79.0, 0.766, 0.232, < 0.21, 0.483 microg g-creatinine(-1), respectively. The mean birth size of the newborn was close to the national average value in Japan. Stepwise multiple regression analysis using birth size as a dependent variable and urinary metal concentrations and covariates as independent variables extracted urinary Cd with a significant negative standardized partial regression coefficient (beta) for BW along with gestational age and maternal BMI. For HC, Sn was selected with a negative beta. The present study suggested that even a low-level Cd body burden of general population has slight but significant negative effect on BW. |
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Authors:
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Sayaka Shirai; Yayoi Suzuki; Jun Yoshinaga; Yoshifumi Mizumoto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering Volume: 45 ISSN: 1532-4117 ISO Abbreviation: J Environ Sci Health A Tox Hazard Subst Environ Eng Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-09 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812551 Medline TA: J Environ Sci Health A Tox Hazard Subst Environ Eng Country: England |
Other Details:
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Languages: eng Pagination: 1468-74 Citation Subset: IM |
Affiliation:
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Department of Environmental Studies, University of Tokyo, Kashiwanoha, Kashiwa, Chiba, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antimony
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urine Arsenic / urine Beryllium / urine Birth Weight Cadmium / urine Copper / urine Environmental Monitoring Female Humans Infant, Newborn Japan Lead / urine Maternal Exposure / adverse effects* Metals, Heavy / urine* Molybdenum / urine Pregnancy Selenium / urine Tin / urine Zinc / urine |
| Chemical | |
Reg. No./Substance:
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0/Metals, Heavy; 7439-92-1/Lead; 7439-98-7/Molybdenum; 7440-31-5/Tin; 7440-36-0/Antimony; 7440-38-2/Arsenic; 7440-41-7/Beryllium; 7440-43-9/Cadmium; 7440-50-8/Copper; 7440-66-6/Zinc; 7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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