| Maternal exposure to influenza and risk of schizophrenia: a 22 year study from The Netherlands. | |
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MedLine Citation:
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PMID: 8642541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated any effect of prenatal exposure to influenza during gestation on subsequent risk of schizophrenia using a national sample from The Netherlands. Dates of births of all Dutch-born schizophrenia (ICD-9) patients (n = 10,630) admitted to hospitals for the first time between 1970 and 1992 were examined in relation to the occurrence of influenza epidemics between 1947 and 1969. As a measure of prevalence of influenza, the number of deaths from influenza per month in The Netherlands was used. A Poisson regression analysis revealed that an increase in the prevalence of influenza 3 months prior to birth was followed by an increase in births of preschizophrenics, although this fell outside statistical significance (p = .11). However, the effect became marked in typical schizophrenics (n = 4726), but not in less typical cases (n = 5389). For typical schizophrenics, the parameter estimate derived from the regression model indicates that there was a 10% increase (95% confidence interval: -1 to 22%) in preschizophrenic births for every 500 deaths from influenza 3 months before birth. |
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Authors:
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N Takei; J Van Os; R M Murray |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of psychiatric research Volume: 29 ISSN: 0022-3956 ISO Abbreviation: J Psychiatr Res Publication Date: 1995 Nov-Dec |
Date Detail:
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Created Date: 1996-07-16 Completed Date: 1996-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376331 Medline TA: J Psychiatr Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 435-45 Citation Subset: IM |
Affiliation:
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Department of Psychological Medicine, King's College Hospital, London, U.K. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cross-Sectional Studies Disease Outbreaks* Female Gestational Age Humans Incidence Infant, Newborn Influenza, Human / epidemiology*, mortality Male Middle Aged Netherlands / epidemiology Pregnancy Prenatal Exposure Delayed Effects* Registries / statistics & numerical data Risk Factors Schizophrenia / epidemiology*, etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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