Document Detail


Maternal exposure to influenza and risk of schizophrenia: a 22 year study from The Netherlands.
MedLine Citation:
PMID:  8642541     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated any effect of prenatal exposure to influenza during gestation on subsequent risk of schizophrenia using a national sample from The Netherlands. Dates of births of all Dutch-born schizophrenia (ICD-9) patients (n = 10,630) admitted to hospitals for the first time between 1970 and 1992 were examined in relation to the occurrence of influenza epidemics between 1947 and 1969. As a measure of prevalence of influenza, the number of deaths from influenza per month in The Netherlands was used. A Poisson regression analysis revealed that an increase in the prevalence of influenza 3 months prior to birth was followed by an increase in births of preschizophrenics, although this fell outside statistical significance (p = .11). However, the effect became marked in typical schizophrenics (n = 4726), but not in less typical cases (n = 5389). For typical schizophrenics, the parameter estimate derived from the regression model indicates that there was a 10% increase (95% confidence interval: -1 to 22%) in preschizophrenic births for every 500 deaths from influenza 3 months before birth.
Authors:
N Takei; J Van Os; R M Murray
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of psychiatric research     Volume:  29     ISSN:  0022-3956     ISO Abbreviation:  J Psychiatr Res     Publication Date:    1995 Nov-Dec
Date Detail:
Created Date:  1996-07-16     Completed Date:  1996-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  435-45     Citation Subset:  IM    
Affiliation:
Department of Psychological Medicine, King's College Hospital, London, U.K.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cross-Sectional Studies
Disease Outbreaks*
Female
Gestational Age
Humans
Incidence
Infant, Newborn
Influenza, Human / epidemiology*,  mortality
Male
Middle Aged
Netherlands / epidemiology
Pregnancy
Prenatal Exposure Delayed Effects*
Registries / statistics & numerical data
Risk Factors
Schizophrenia / epidemiology*,  etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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