Document Detail

Maternal exposure to household chemicals and risk of infant leukemia: a report from the Children's Oncology Group.
MedLine Citation:
PMID:  21691732     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Utilizing data from the largest study to date, we examined associations between maternal preconception/prenatal exposure to household chemicals and infant acute leukemia.
METHODS: We present data from a Children's Oncology Group case-control study of 443 infants (<1 year of age) diagnosed with acute leukemia [including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)] between 1996 and 2006 and 324 population controls. Mothers recalled household chemical use 1 month before and throughout pregnancy. We used unconditional logistic regression adjusted for birth year, maternal age, and race/ethnicity to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS: We did not find evidence for an association between infant leukemia and eight of nine chemical categories. However, exposure to petroleum products during pregnancy was associated with AML (OR = 2.54; 95% CI:1.40-4.62) and leukemia without mixed lineage leukemia (MLL) gene rearrangements ("MLL-") (OR = 2.69; 95% CI: 1.47-4.93). No associations were observed for exposure in the month before pregnancy.
CONCLUSIONS: Gestational exposure to petroleum products was associated with infant leukemia, particularly AML, and MLL- cases. Benzene is implicated as a potential carcinogen within this exposure category, but a clear biological mechanism has yet to be elucidated.
Megan E Slater; Amy M Linabery; Logan G Spector; Kimberly J Johnson; Joanne M Hilden; Nyla A Heerema; Leslie L Robison; Julie A Ross
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-06-21
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  22     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-20     Completed Date:  2011-12-29     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1197-204     Citation Subset:  IM    
Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
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MeSH Terms
Case-Control Studies
Environmental Exposure / adverse effects*
Household Products / poisoning*
Leukemia, Myeloid, Acute / chemically induced*
Maternal Exposure / adverse effects*
Prenatal Exposure Delayed Effects*
Risk Factors
Grant Support
P30 CA077598/CA/NCI NIH HHS; P30 CA77598/CA/NCI NIH HHS; R01 CA079940/CA/NCI NIH HHS; R01 CA79940/CA/NCI NIH HHS; T32 CA099936/CA/NCI NIH HHS; T32 CA99936/CA/NCI NIH HHS; U10 CA013539/CA/NCI NIH HHS; U10 CA098413/CA/NCI NIH HHS; U10 CA098543/CA/NCI NIH HHS; U10 CA13539/CA/NCI NIH HHS; U10 CA98413/CA/NCI NIH HHS; U10 CA98543/CA/NCI NIH HHS

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