| Maternal exposure to household chemicals and risk of infant leukemia: a report from the Children's Oncology Group. | |
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MedLine Citation:
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PMID: 21691732 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Utilizing data from the largest study to date, we examined associations between maternal preconception/prenatal exposure to household chemicals and infant acute leukemia. METHODS: We present data from a Children's Oncology Group case-control study of 443 infants (<1 year of age) diagnosed with acute leukemia [including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)] between 1996 and 2006 and 324 population controls. Mothers recalled household chemical use 1 month before and throughout pregnancy. We used unconditional logistic regression adjusted for birth year, maternal age, and race/ethnicity to calculate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: We did not find evidence for an association between infant leukemia and eight of nine chemical categories. However, exposure to petroleum products during pregnancy was associated with AML (OR = 2.54; 95% CI:1.40-4.62) and leukemia without mixed lineage leukemia (MLL) gene rearrangements ("MLL-") (OR = 2.69; 95% CI: 1.47-4.93). No associations were observed for exposure in the month before pregnancy. CONCLUSIONS: Gestational exposure to petroleum products was associated with infant leukemia, particularly AML, and MLL- cases. Benzene is implicated as a potential carcinogen within this exposure category, but a clear biological mechanism has yet to be elucidated. |
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Authors:
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Megan E Slater; Amy M Linabery; Logan G Spector; Kimberly J Johnson; Joanne M Hilden; Nyla A Heerema; Leslie L Robison; Julie A Ross |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-06-21 |
Journal Detail:
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Title: Cancer causes & control : CCC Volume: 22 ISSN: 1573-7225 ISO Abbreviation: Cancer Causes Control Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-20 Completed Date: 2011-12-29 Revised Date: 2013-05-06 |
Medline Journal Info:
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Nlm Unique ID: 9100846 Medline TA: Cancer Causes Control Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1197-204 Citation Subset: IM |
Affiliation:
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Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Environmental Exposure / adverse effects* Female Household Products / poisoning* Humans Infant Leukemia, Myeloid, Acute / chemically induced* Male Maternal Exposure / adverse effects* Pregnancy Prenatal Exposure Delayed Effects* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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P30 CA77598/CA/NCI NIH HHS; R01 CA079940/CA/NCI NIH HHS; R01 CA79940/CA/NCI NIH HHS; T32 CA099936/CA/NCI NIH HHS; T32 CA99936/CA/NCI NIH HHS; U10 CA098543/CA/NCI NIH HHS; U10 CA13539/CA/NCI NIH HHS; U10 CA98413/CA/NCI NIH HHS; U10 CA98543/CA/NCI NIH HHS |
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