Document Detail

Maternal exposure to floricultural work during pregnancy, PON1 Q192R polymorphisms and the risk of low birth weight.
MedLine Citation:
PMID:  19646734     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although there is evidence from animal studies of impaired reproductive function by exposure to organophosphates (OP), the effects on birth weight have not been sufficiently evaluated in epidemiological studies. Paraoxonase (PON1) detoxifies organophosphates by cleavage of active oxons. Some PON1 gene polymorphisms could reduce the enzyme activity and increase susceptibility to OP toxicity. OBJECTIVE: To assess the association between maternal exposure to floriculture during pregnancy and the risk of low birth weight (<2500 g) in their offspring, as well as to evaluate the interaction between this exposure and maternal genotype for PON1 Q192R polymorphisms. MATERIALS AND METHODS: A cross sectional study was carried out in two Mexican states (States of Mexico and Morelos) with high frequencies of greenhouse activity. We interviewed and collected blood samples from 264 females (floriculturists or partners of floricultural workers) who became pregnant during the 10 years prior to the interview. The questionnaire measured socioeconomic characteristics, tobacco and alcohol consumption, diseases and occupational and reproductive history. We also applied a food frequency questionnaire. Information was obtained pertaining to 467 pregnancies. DNA was extracted from white cells, and PON1 genotype was determined by Restriction Fragment Length Polymorphism for Q192R polymorphisms. Results were analyzed with generalized estimating equations models. RESULTS: After adjusting for potential confounders, we detected a statistically significant interaction between maternal exposure to flower growing work during pregnancy and PON1 Q192R polymorphisms on risk of low birth weight. The risk of having a baby with LBW is nearly six times higher if a mother is a floriculture worker during pregnancy and has PON1 192RR genotype (OR 5.93, 95% CI 1.28, 27.5). CONCLUSION: These results suggest that the interaction between maternal floriculture work during pregnancy and 192RR PON1 genotype increases the probability of having children with LBW.
G Moreno-Banda; J Blanco-Muñoz; M Lacasaña; S J Rothenberg; C Aguilar-Garduño; R Gamboa; O Pérez-Méndez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-30
Journal Detail:
Title:  The Science of the total environment     Volume:  407     ISSN:  1879-1026     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-21     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  5478-85     Citation Subset:  IM    
Population Health Research Center, National Institute of Public Health, Avenida Universidad 655, Colonia Santa María Ahuacatitlán, 62508 Cuernavaca, Morelos, Mexico.
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MeSH Terms
Aryldialkylphosphatase / genetics*
Cross-Sectional Studies
Infant, Low Birth Weight*
Infant, Newborn
Maternal Exposure*
Occupational Exposure*
Phosphoric Acid Esters / toxicity
Polymorphism, Genetic*
Risk Assessment
Reg. No./Substance:
0/Phosphoric Acid Esters; EC; EC protein, human

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