Document Detail


Maternal epilepsy and offsprings' adult intelligence: a population-based study from Norway.
MedLine Citation:
PMID:  17521348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: We examined if children of mothers with epilepsy had normal intelligence, speculating that either epilepsy or its therapy might affect this parameter. METHODS: In a population-based cohort study in Norway, information on maternal epilepsy reported to the Medical Birth Registry of Norway, 1967-1979 was linked to information on 18-19-year-old men's intellectual ability and anthropometric measures ascertained by the Norwegian Conscripts Service, 1984-1999. The standardized intelligence test (IQ score) was reported as single-digit standard scores with values from 1 to 9. No individual information on antiepileptic drug therapy was available. RESULTS: Mean IQ score was lower in 1,207 conscripts whose mothers had epilepsy reported on the birth notification form, as compared with 316,554 conscripts of mothers without epilepsy; 4.8 (standard deviation 1.8) versus 5.2(1.8), p < 0.001, respectively. This difference remained after adjustment for maternal education, maternal age, birth order, marital status, year of birth, and weight and length at birth. When comparing men with and without reported maternal epilepsy, the odds ratio of having an IQ score < or = 3 was 1.6 (95% confidence interval: 1.4-1.8), which was unaffected by adjustment for confounding factors. Mean height among conscripts of mothers with and without epilepsy measured 178.6 and 179.9 cm, respectively, a difference of 1.3 cm (p < 0.001). CONCLUSIONS: We observed that almost 20 years after birth, maternal epilepsy was associated with reduced IQ score and also shorter adult height in male offspring. We do not know whether these findings will persist when epilepsy is better treated with the newer and safer generation of antiepileptic drugs.
Authors:
Nina Oyen; Stein E Vollset; Martha G Eide; Tor Bjerkedal; Rolv Skjaerven
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-23
Journal Detail:
Title:  Epilepsia     Volume:  48     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-10     Completed Date:  2007-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1731-8     Citation Subset:  IM    
Affiliation:
Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway. noy@ssi.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Adult Children / psychology
Anticonvulsants / adverse effects*,  therapeutic use
Birth Order
Body Height / drug effects
Child
Child of Impaired Parents*
Cohort Studies
Epilepsy / diagnosis,  drug therapy*,  epidemiology*
Female
Follow-Up Studies
Humans
Intelligence / classification*
Intelligence Tests / statistics & numerical data
Male
Maternal Exposure / statistics & numerical data
Maternal-Fetal Exchange
Mental Retardation / diagnosis,  epidemiology
Military Personnel / statistics & numerical data
Norway / epidemiology
Pregnancy
Pregnancy Complications / diagnosis,  epidemiology*
Prenatal Exposure Delayed Effects / diagnosis*,  epidemiology
Chemical
Reg. No./Substance:
0/Anticonvulsants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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