| Maternal endotoxemia, fetal anomalies, and central nervous system damage: a rat model of a human problem. | |
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MedLine Citation:
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PMID: 1108657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endotoxemia is a common consequence of the gram-negative urinary tract infections that complicate human pregnancies. Only rarely, however, have the effects of maternal endotoxemia been evaluated by animal experiments or by human investigations. Data of the Collaborative Perinatal Study suggest an association between maternal endotoxemia and fetal central nervous system damage. For these reasons we performed controlled studies of the fetal effects of treatment of pregnant rats, at appropriate gestational ages, with E. coli endotoxin. We found a maximum 7 per cent incidence of fetal anomalies in the treated animals but no anomalies in controls. Placental light microscopy examinations indicated the mechanism to include Shwartzman-lixemia produces periventricular leukomalacia. We obtained an incidence of neuronal necrosis in treated fetuses that was 10 times greater than in control fetuses. It is therefore of importance that additional studies of the pathologic effects of endotoxin be performed. |
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Authors:
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A Ornoy; G Altshuler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 124 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1976 Jan |
Date Detail:
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Created Date: 1976-03-15 Completed Date: 1976-03-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 196-204 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteriuria / complications Central Nervous System / abnormalities* Congenital Abnormalities / etiology* Disease Models, Animal Endotoxins / blood* Escherichia coli Infections / complications Female Fetal Resorption / etiology Gestational Age Humans Pregnancy Pregnancy Complications, Infectious* Rats Shwartzman Phenomenon / etiology |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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