Document Detail

Maternal and early postnatal polychlorinated biphenyl exposure in relation to total serum immunoglobulin concentrations in 6-month-old infants.
MedLine Citation:
PMID:  21299357     Owner:  NLM     Status:  MEDLINE    
Animal data indicate that developmental tetrachlorodibenzo-p-dioxin exposure alters immune function; however, the potential immunotoxicity of dioxin-like and non-dioxin-like polychlorinated biphenyls (PCBs) in the developing infant is an understudied area. The aim of the current study is to examine the association between maternal and early postnatal PCB concentrations in relation to total infant serum immunoglobulin concentrations determined at 6-months-of-age. We selected 384 mother-infant pairs participating in a birth cohort study in Eastern Slovakia. PCB concentrations of several congeners were determined in maternal and cord serum samples and in infant serum samples collected at 6-months-of-age using gas chromatography with electron capture detection. Total immunoglobulin (Ig) G, A, and M concentrations were determined by nephelometry, and IgE concentrations were determined by enzyme-linked immunoassay. Linear regression models with adjustment for potential confounding factors were used to estimate the associations between maternal, cord, and 6-month infant PCB concentrations and total serum immunoglobulins. The median maternal serum concentration of PCB-153 was 140?ng/g lipid, ?10-fold higher than concentrations in childbearing-age women in the United States during the same period. Maternal, cord, or 6-month infant PCB concentrations were not associated with total serum immunoglobulin levels at 6 months, regardless of the timing of PCB exposure, PCB congener, or specific immunoglobulin. In this population, which has high PCB concentrations relative to most populations in the world today, we did not observe any association between maternal and early postnatal PCB concentrations and total immunoglobulin measures of IgG, IgA, IgM, or IgE.
Todd A Jusko; Anneclaire J De Roos; Stephen M Schwartz; B Paige Lawrence; Lubica Palkovicova; Tomas Nemessanyi; Beata Drobna; Anna Fabisikova; Anton Kocan; Eva Jahnova; Terrance J Kavanagh; Tomas Trnovec; Irva Hertz-Picciotto
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of immunotoxicology     Volume:  8     ISSN:  1547-6901     ISO Abbreviation:  J Immunotoxicol     Publication Date:    2011 Jan-Mar
Date Detail:
Created Date:  2011-02-08     Completed Date:  2011-05-20     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  101201960     Medline TA:  J Immunotoxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
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MeSH Terms
Environmental Pollutants / blood,  toxicity*
Fetal Blood / chemistry
Immunoglobulins / blood*
Linear Models
Maternal Exposure / adverse effects*
Maternal-Fetal Exchange*
Multivariate Analysis
Polychlorinated Biphenyls / blood,  toxicity*
Young Adult
Grant Support
R01 CA096525/CA/NCI NIH HHS; R01 CA096525-04S1/CA/NCI NIH HHS; R01-CA096525/CA/NCI NIH HHS; T32 ES007262/ES/NIEHS NIH HHS; T32 ES007262-15S2/ES/NIEHS NIH HHS; T32 RR023256/RR/NCRR NIH HHS; T32 RR023256-01/RR/NCRR NIH HHS; T32-ES007262/ES/NIEHS NIH HHS; T32-RR023256/RR/NCRR NIH HHS; TL1 RR025016/RR/NCRR NIH HHS; U01 ES016127/ES/NIEHS NIH HHS; U01 ES016127-01/ES/NIEHS NIH HHS; U01-ES016127/ES/NIEHS NIH HHS
Reg. No./Substance:
0/Environmental Pollutants; 0/Immunoglobulins; DFC2HB4I0K/Polychlorinated Biphenyls

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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