Document Detail

Maternal drug use and infant cleft lip/palate with special reference to corticoids.
MedLine Citation:
PMID:  14577813     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the association between maternal drug use in early pregnancy and orofacial cleft in the infant.
DESIGN: Register analysis based on prospectively collected information.
PATIENTS: All delivered women in Sweden July 1, 1995, through December 31, 2001.
MAIN OUTCOME MEASURE: Presence of orofacial cleft in infant.
RESULTS: Prospective information on maternal drug use during the first trimester, as reported in early pregnancy, was studied in 1142 infants with orofacial clefts, isolated or with other malformations, excluding chromosome anomalies. Any drug use was not associated with clefts (odds ratio [OR] = 0.98, 95% confidence interval [95% CI] = 0.85 to 1.13), with isolated clefts (OR = 0.92) with isolated median cleft palate (OR = 1.03, 95% CI = 0.79 to 1.36) or with isolated cleft lip with or without cleft palate (OR = 0.86, 95% CI = 0.71 to 1.05). Reported use of multivitamins, folic acid, or B(12) was not associated with a decrease in orofacial cleft risk (OR = 1.00, 95% CI = 0.63 to 1.52). ORs above 2 were seen for some drugs: sulfasalazine, naproxen, and anticonvulsants, but only a few exposed cases occurred. An association between glucocorticoid use and infant cleft was indicated and seemed to be strongest for median cleft palate.
CONCLUSION: Maternal drug use seems to play only a small role for the origin of orofacial clefts, at least in Sweden.
Bengt Källén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association     Volume:  40     ISSN:  1055-6656     ISO Abbreviation:  Cleft Palate Craniofac. J.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-27     Completed Date:  2004-02-05     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  9102566     Medline TA:  Cleft Palate Craniofac J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  624-8     Citation Subset:  D; IM    
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MeSH Terms
Abnormalities, Drug-Induced / epidemiology*
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
Anticonvulsants / administration & dosage
Cleft Lip / epidemiology*
Cleft Palate / epidemiology*
Confidence Intervals
Folic Acid / administration & dosage
Glucocorticoids / administration & dosage*
Infant, Newborn
Naproxen / administration & dosage
Odds Ratio
Pharmaceutical Preparations*
Pregnancy Trimester, First
Prospective Studies
Sulfasalazine / administration & dosage
Sweden / epidemiology
Vitamins / administration & dosage
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Anticonvulsants; 0/Glucocorticoids; 0/Pharmaceutical Preparations; 0/Vitamins; 3XC8GUZ6CB/Sulfasalazine; 57Y76R9ATQ/Naproxen; 935E97BOY8/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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