| Maternal drug use and infant cleft lip/palate with special reference to corticoids. | |
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MedLine Citation:
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PMID: 14577813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the association between maternal drug use in early pregnancy and orofacial cleft in the infant. DESIGN: Register analysis based on prospectively collected information.Patients: All delivered women in Sweden July 1, 1995, through December 31, 2001. MAIN OUTCOME MEASURE: Presence of orofacial cleft in infant. RESULTS: Prospective information on maternal drug use during the first trimester, as reported in early pregnancy, was studied in 1142 infants with orofacial clefts, isolated or with other malformations, excluding chromosome anomalies. Any drug use was not associated with clefts (odds ratio [OR] = 0.98, 95% confidence interval [95% CI] = 0.85 to 1.13), with isolated clefts (OR = 0.92) with isolated median cleft palate (OR = 1.03, 95% CI = 0.79 to 1.36) or with isolated cleft lip with or without cleft palate (OR = 0.86, 95% CI = 0.71 to 1.05). Reported use of multivitamins, folic acid, or B(12) was not associated with a decrease in orofacial cleft risk (OR = 1.00, 95% CI = 0.63 to 1.52). ORs above 2 were seen for some drugs: sulfasalazine, naproxen, and anticonvulsants, but only a few exposed cases occurred. An association between glucocorticoid use and infant cleft was indicated and seemed to be strongest for median cleft palate. CONCLUSION: Maternal drug use seems to play only a small role for the origin of orofacial clefts, at least in Sweden. |
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Authors:
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Bengt Källén |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association Volume: 40 ISSN: 1055-6656 ISO Abbreviation: Cleft Palate Craniofac. J. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-10-27 Completed Date: 2004-02-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9102566 Medline TA: Cleft Palate Craniofac J Country: United States |
Other Details:
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Languages: eng Pagination: 624-8 Citation Subset: D; IM |
Affiliation:
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Tornblad Institute, University of Lund, Sweden. embryol@embryol.lu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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epidemiology* Anti-Inflammatory Agents, Non-Steroidal / administration & dosage Anticonvulsants / administration & dosage Cleft Lip / epidemiology* Cleft Palate / epidemiology* Confidence Intervals Female Folic Acid / administration & dosage Glucocorticoids / administration & dosage* Humans Infant, Newborn Naproxen / administration & dosage Odds Ratio Pharmaceutical Preparations* Pregnancy Pregnancy Trimester, First Prospective Studies Registries Sulfasalazine / administration & dosage Sweden / epidemiology Vitamins / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Anticonvulsants; 0/Glucocorticoids; 0/Pharmaceutical Preparations; 0/Vitamins; 22204-53-1/Naproxen; 59-30-3/Folic Acid; 599-79-1/Sulfasalazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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