| Maternal docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice. | |
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MedLine Citation:
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PMID: 21178083 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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DHA is a long-chain fatty acid that has potent antiinflammatory properties. Whereas maternal DHA dietary supplementation has been shown to improve cognitive development in infants fed DHA-supplemented milk, the antiinflammatory effects of maternal DHA supplementation on the developing fetus and neonate have not been extensively explored. Pregnant C3H/HeN dams were fed purified control or DHA-supplemented diets (~0.25% of total fat) at embryonic d 16 and consumed these diets throughout the study. At birth, the nursing mouse pups were placed in room air (RA; 21% O(2)) or >95% O(2) (hyperoxia) for up to 7 d. These studies tested the hypothesis that maternal DHA supplementation would decrease inflammation and improve alveolarization in the lungs of newborn mouse pups exposed to hyperoxia. Survival, inflammatory responses, and lung growth were compared among control diet/RA, DHA/RA, control/O(2), and DHA/O(2) pups. There were fewer neutrophils and macrophages in lung tissues from pups nursed by DHA-supplemented dams than in those nursed by dams fed the control diet at 7 d of hyperoxia exposure (P < 0.015). Although differences due to hyperoxia exposure were observed, maternal diet did not affect keratinocyte-derived chemokine, macrophage inflammatory protein-2, IL-1β, or TNFα mRNA levels in pup tissues. Hyperoxia also induced NF-κB activity, but maternal diet did not affect NF-κB or PPARγ activities. In mice, DHA supplementation decreases leukocyte infiltration in the offspring exposed to hyperoxia, suggesting a potential role for DHA supplementation as a therapy to reduce inflammation in preterm infants. |
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Authors:
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Lynette K Rogers; Christina J Valentine; Michael Pennell; Markus Velten; Rodney D Britt; Kelly Dingess; Xuilan Zhao; Stephen E Welty; Trent E Tipple |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-12-22 |
Journal Detail:
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Title: The Journal of nutrition Volume: 141 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-21 Completed Date: 2011-02-23 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 214-22 Citation Subset: IM |
Affiliation:
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Center for Perinatal Research, The Ohio State University, Columbus, OH 43205, USA. lynette.rogers@nationwidechildrens.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Anti-Inflammatory Agents / pharmacology, therapeutic use* Cell Count Dietary Fats / administration & dosage Dietary Supplements Docosahexaenoic Acids / pharmacology, therapeutic use* Female Hyperoxia* Lung / drug effects*, immunology, physiology Macrophages Mice Mice, Inbred C3H Neutrophil Infiltration / drug effects* Neutrophils Phagocytes Pneumonia / drug therapy*, etiology, immunology Pregnancy Prenatal Nutritional Physiological Phenomena / immunology Pulmonary Alveoli / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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K08 HL093365-02/HL/NHLBI NIH HHS; K08 HL093365-03/HL/NHLBI NIH HHS; K12 HD043372/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Dietary Fats; 25167-62-8/Docosahexaenoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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