Document Detail

Maternal dietary glycaemic intake during pregnancy and the risk of birth defects.
MedLine Citation:
PMID:  21649676     Owner:  NLM     Status:  MEDLINE    
High sugar intake has been linked to fetal anomalies in the presence and absence of insulin resistance. Using dietary data collected in the Boston University Slone Epidemiology Birth Defects Study, we examined whether high dietary glycaemic index (dGI) or load (dGL) increased the risk of birth defects. Non-diabetic mothers of 1921 cases and 704 controls were interviewed within 6 months of delivery (1988-98) about pregnancy events and exposures, including a 99-item food frequency questionnaire. Case groups included amniotic bands, craniosynostosis, gastroschisis, hypospadias, small intestinal defects, anorectal defects, limb reductions, omphalocele, cleft lip and/or palate, renal agenesis, and tracheoesophageal fistula. Cubic splines were used to determine cut-point values for high dGI and dGL in relation to the risk of each birth defect. The cut-points were used in logistic regression models to calculate odds ratios (OR) and 95% confidence intervals [CI]. Control mothers in the lowest quartile of glycaemic intake were more likely to be non-Hispanic White, ≥ 30 years of age, have higher family income, have a normal body mass index and reside in Boston. Findings were null for most case groups. The anorectal defect case group was found to have elevated risks for dGL [adjusted OR: 2.4; 95% CI: 1.1, 4.9], while estimates for dGI were elevated for the amniotic band case group [adjusted OR: 3.0; 95% CI: 1.1, 8.1]. Because this is the first paper (to our knowledge) to explore dGI and dGL in relation to a spectrum of birth defects, additional studies are needed.
Mahsa M Yazdy; Allen A Mitchell; Simin Liu; Martha M Werler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-04-24
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  25     ISSN:  1365-3016     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-08     Completed Date:  2011-12-01     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  340-6     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Slone Epidemiology Center at Boston University, Boston, MA 02215, USA.
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MeSH Terms
Canada / epidemiology
Case-Control Studies
Congenital Abnormalities / epidemiology,  etiology*
Dietary Sucrose / adverse effects*
Glycemic Index*
Risk Factors
Socioeconomic Factors
United States / epidemiology
Young Adult
Grant Support
Reg. No./Substance:
0/Dietary Sucrose

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