| Maternal diet modulates the risk for neural tube defects in a mouse model of diabetic pregnancy. | |
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MedLine Citation:
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PMID: 20868740 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnancies complicated by maternal diabetes have long been known to carry a higher risk for congenital malformations, such as neural tube defects. Using the FVB inbred mouse strain and the Streptozotocin-induced diabetes model, we tested whether the incidence of neural tube defects in diabetic pregnancies can be modulated by maternal diet. In a comparison of two commercial mouse diets, which are considered nutritionally replete, we found that maternal consumption of the unfavorable diet was associated with a more than 3-fold higher rate of neural tube defects. Our results demonstrate that maternal diet can act as a modifier of the risk for abnormal development in high-risk pregnancies, and provide support for the possibility that neural tube defects in human diabetic pregnancies might be preventable by optimized maternal nutrition. |
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Authors:
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Claudia Kappen; Claudia Kruger; Jacalyn MacGowan; J Michael Salbaum |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-22 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 31 ISSN: 1873-1708 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-02-08 Completed Date: 2011-05-17 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 41-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA. Claudia.Kappen@pbrc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed Animal Nutritional Physiological Phenomena* Animals Diabetes Mellitus, Experimental* Effect Modifier, Epidemiologic Embryo, Mammalian / metabolism Embryonic Development Female Maternal Nutritional Physiological Phenomena* Mice Neural Tube Defects / embryology, epidemiology, prevention & control* Pregnancy Pregnancy in Diabetics* Risk |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD037804-10/HD/NICHD NIH HHS; R01 HD055528-04/HD/NICHD NIH HHS; R01-HD055528/HD/NICHD NIH HHS; R01-HD37804/HD/NICHD NIH HHS |
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