Document Detail


Maternal diet modulates the risk for neural tube defects in a mouse model of diabetic pregnancy.
MedLine Citation:
PMID:  20868740     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancies complicated by maternal diabetes have long been known to carry a higher risk for congenital malformations, such as neural tube defects. Using the FVB inbred mouse strain and the Streptozotocin-induced diabetes model, we tested whether the incidence of neural tube defects in diabetic pregnancies can be modulated by maternal diet. In a comparison of two commercial mouse diets, which are considered nutritionally replete, we found that maternal consumption of the unfavorable diet was associated with a more than 3-fold higher rate of neural tube defects. Our results demonstrate that maternal diet can act as a modifier of the risk for abnormal development in high-risk pregnancies, and provide support for the possibility that neural tube defects in human diabetic pregnancies might be preventable by optimized maternal nutrition.
Authors:
Claudia Kappen; Claudia Kruger; Jacalyn MacGowan; J Michael Salbaum
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-09-22
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  31     ISSN:  1873-1708     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-02-08     Completed Date:  2011-05-17     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animal Feed
Animal Nutritional Physiological Phenomena*
Animals
Diabetes Mellitus, Experimental*
Effect Modifier, Epidemiologic
Embryo, Mammalian / metabolism
Embryonic Development
Female
Maternal Nutritional Physiological Phenomena*
Mice
Neural Tube Defects / embryology,  epidemiology,  prevention & control*
Pregnancy
Pregnancy in Diabetics*
Risk
Grant Support
ID/Acronym/Agency:
R01 HD037804/HD/NICHD NIH HHS; R01 HD037804-10/HD/NICHD NIH HHS; R01 HD055528/HD/NICHD NIH HHS; R01 HD055528-04/HD/NICHD NIH HHS; R01-HD055528/HD/NICHD NIH HHS; R01-HD37804/HD/NICHD NIH HHS
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