| Maternal diet and cord blood leptin and adiponectin concentrations at birth. | |
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MedLine Citation:
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PMID: 20363059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: The purpose of this study was to determine the effects of total energy intake, macronutrient intake, and maternal adherence to Mediterranean diet or Alternative Healthy Eating Index (AHEI) on cord blood leptin and adiponectin levels, which have been associated with childhood adiposity. METHODS: We used multivariable linear regression to assess associations of maternal diet, averaged over 1st and 2nd trimesters, with cord blood adipokines of 780 women from the prospective cohort study Project Viva. RESULTS: Mean (SD) energy intake during pregnancy was 2135 (596) kcal. Mean (SD) cord blood levels of leptin and adiponectin were 9.0 (6.6) ng/ml and 28.6 (6.7) μg/ml, respectively. Neither closer adherence to a Mediterranean/AHEI pattern diet nor energy intake was associated with either cord blood leptin or adiponectin. Protein intake was associated with both marginally lower leptin (-0.22 ng/ml [95% CI -0.41, -0.02] for each 1% of energy) and adiponectin (-0.25 μg/ml [95% CI -0.48, -0.02]). CONCLUSIONS: Closer adherence to a Mediterranean/AHEI pattern diet during pregnancy was not associated with cord blood leptin or adiponectin. Maternal protein intake was weakly but significantly associated with lower cord blood leptin and adiponectin. |
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Authors:
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Christos S Mantzoros; Laura Sweeney; Catherine J Williams; Emily Oken; Theodoros Kelesidis; Sheryl L Rifas-Shiman; Matthew W Gillman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-04-03 |
Journal Detail:
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Title: Clinical nutrition (Edinburgh, Scotland) Volume: 29 ISSN: 1532-1983 ISO Abbreviation: Clin Nutr Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2011-01-20 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 622-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Affiliation:
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Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, ST816, Boston, MA 02215, USA. cmantzor@bidmc.harvard.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood*,
metabolism Adiposity Adult Cohort Studies Diet, Mediterranean Dietary Proteins / metabolism* Energy Intake Female Fetal Blood / metabolism* Humans Infant, Newborn Leptin / blood*, metabolism Linear Models Male Multivariate Analysis Pregnancy Prenatal Nutritional Physiological Phenomena* |
| Grant Support | |
ID/Acronym/Agency:
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081913//PHS HHS; DK081913/DK/NIDDK NIH HHS; DK58785/DK/NIDDK NIH HHS; DK79929/DK/NIDDK NIH HHS; HD 034568/HD/NICHD NIH HHS; HL 64925/HL/NHLBI NIH HHS; HL 68041/HL/NHLBI NIH HHS; K24 DK081913-02/DK/NIDDK NIH HHS; K24 DK081913-04/DK/NIDDK NIH HHS; K24 HL068041-06/HL/NHLBI NIH HHS; K24 HL068041-07/HL/NHLBI NIH HHS; P30 DK040561-15/DK/NIDDK NIH HHS; R01 CA095589-08/CA/NCI NIH HHS; R01 DK058785-08/DK/NIDDK NIH HHS; R01 DK058845-10/DK/NIDDK NIH HHS; R01 DK079929-02/DK/NIDDK NIH HHS; R01 DK079929-04/DK/NIDDK NIH HHS; R01 HD034568-07/HD/NICHD NIH HHS; R01 HL064925-06/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Dietary Proteins; 0/Leptin |
| Comments/Corrections | |
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