Document Detail

Maternal deprivation, acute respiratory infections and immune regulation.
MedLine Citation:
PMID:  17127780     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The study was designed to investigate the acute respiratory disease incidence (DI) in deprived infants and test the hypothesis if maternal deprivation effects the processes of immunoregulation in infants. METHODS: The prospective study during 1 year in Tbilisi Infant's House was performed. Cohort of 136 infants at age from 1 to 24 months without any congenital abnormalities formed the basic group. The cohort of 136 healthy infants at age 1 to 24 months of the same population living under the maternal care in three shelters of Tbilisi region was randomized as a control. The study included: DI, age of first attack, duration of illness, outcome, plasma immune parameters. RESULTS: The data have demonstrated that maternal deprivation induces a marked increase in the severity of acute respiratory disease among infants. DI was twice as much in deprived children as in control group. Moreover, there was diagnosed the disruption of normal correlations between plasma CD3, CD4 and CD8 in infants under maternal deprivation. CONCLUSION: Maternal deprivation induces changes in processes of immunoregulation in infants resulted in elevation of acute respiratory DI among them.
K Gogberashvili
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  73     ISSN:  0973-7693     ISO Abbreviation:  Indian J Pediatr     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-27     Completed Date:  2006-11-30     Revised Date:  2009-07-15    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  995-7     Citation Subset:  IM    
Department of Pediatrics and Adolescents Medicine, Tbilisi State Medical University, Georgia.
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MeSH Terms
Acute Disease
Cohort Studies
Homeostasis* / immunology
Infant Care* / statistics & numerical data
Mother-Child Relations
Prospective Studies
Respiratory Tract Diseases / epidemiology,  immunology*

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