| Maternal cured meat consumption during pregnancy and risk of paediatric brain tumour in offspring: potentially harmful levels of intake. | |
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MedLine Citation:
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PMID: 11299090 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe the relationship between specific levels of nitrite intake from cured meat consumption during pregnancy and the relative risk of paediatric brain tumours in the offspring. DESIGN: Exposure data were previously collected for a population-based case-control study of paediatric brain tumours; data on nitrite content were obtained by a comprehensive literature review of surveys of residual nitrite content in cured meats published in the USA and Canada. The level of nitrite intake for each mother was predicted by year of pregnancy based on survey results. Dose-response was evaluated both categorically and continuously using polynomial and quadratic spline regression. SETTING: The US west coast: Los Angeles County, the San Francisco-Oakland Bay Area and the Seattle-Puget Sound area. SUBJECTS: There were 540 cases diagnosed between 1984 and 1990 at ages varying from 0 to 19 years, and 801 controls frequency-matched by geographic area, age and birth year. RESULTS: In general, survey results suggest a trend of decreasing nitrite levels in cured meats over time. We observed a moderate increase in brain tumour risk in the offspring of mothers with relatively low levels of nitrite consumption from cured meats during pregnancy, and a two- to three-fold risk increase in offspring of mothers who consumed 3 mg day-1 nitrite from cured meats (about 125 g day-1 of cured meat consumption throughout the pregnancy). CONCLUSIONS: A substantial risk of paediatric brain tumour appears to be associated with relatively high levels of maternal cured meat consumption during pregnancy. A more scientifically valid approach than a literature review to estimate nitrite intake from cured meats and data from a large group of highly exposed subjects would be useful in determining potentially harmful levels. |
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Authors:
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J M Pogoda; S Preston-Martin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Public health nutrition Volume: 4 ISSN: 1368-9800 ISO Abbreviation: Public Health Nutr Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-12 Completed Date: 2001-08-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9808463 Medline TA: Public Health Nutr Country: England |
Other Details:
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Languages: eng Pagination: 183-9 Citation Subset: IM |
Affiliation:
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1Statology, 10355 Pine Cone Way, Truckee, CA 96161, USA. jpogoda@statology.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Neoplasms / epidemiology*, etiology California / epidemiology Case-Control Studies Child Child, Preschool Diet Surveys Dose-Response Relationship, Drug Female Humans Infant Infant, Newborn Meat Products / adverse effects* Nitrites / adverse effects*, metabolism Nitroso Compounds / adverse effects* Pregnancy Prenatal Exposure Delayed Effects* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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CA47082/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nitrites; 0/Nitroso Compounds |
| Comments/Corrections | |
Comment In:
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Public Health Nutr. 2001 Dec;4(6):1303-5
[PMID:
11796094
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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