Document Detail


Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems.
MedLine Citation:
PMID:  22529357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stress-related variation in the intrauterine milieu may impact brain development and emergent function, with long-term implications in terms of susceptibility for affective disorders. Studies in animals suggest limbic regions in the developing brain are particularly sensitive to exposure to the stress hormone cortisol. However, the nature, magnitude, and time course of these effects have not yet been adequately characterized in humans. A prospective, longitudinal study was conducted in 65 normal, healthy mother-child dyads to examine the association of maternal cortisol in early, mid-, and late gestation with subsequent measures at approximately 7 y age of child amygdala and hippocampus volume and affective problems. After accounting for the effects of potential confounding pre- and postnatal factors, higher maternal cortisol levels in earlier but not later gestation was associated with a larger right amygdala volume in girls (a 1 SD increase in cortisol was associated with a 6.4% increase in right amygdala volume), but not in boys. Moreover, higher maternal cortisol levels in early gestation was associated with more affective problems in girls, and this association was mediated, in part, by amygdala volume. No association between maternal cortisol in pregnancy and child hippocampus volume was observed in either sex. The current findings represent, to the best of our knowledge, the first report linking maternal stress hormone levels in human pregnancy with subsequent child amygdala volume and affect. The results underscore the importance of the intrauterine environment and suggest the origins of neuropsychiatric disorders may have their foundations early in life.
Authors:
Claudia Buss; Elysia Poggi Davis; Babak Shahbaba; Jens C Pruessner; Kevin Head; Curt A Sandman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-04-23
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-16     Completed Date:  2012-07-27     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1312-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Amygdala / metabolism,  pathology*
California
Child
Cohort Studies
Female
Hippocampus / metabolism,  pathology*
Humans
Hydrocortisone / metabolism*
Longitudinal Studies
Magnetic Resonance Imaging
Male
Mood Disorders / etiology*,  metabolism,  pathology
Organ Size / physiology
Pregnancy
Prenatal Exposure Delayed Effects / metabolism*
Prospective Studies
Regression Analysis
Saliva / chemistry
Sex Factors
Grant Support
ID/Acronym/Agency:
HD-28413/HD/NICHD NIH HHS; HD-51852/HD/NICHD NIH HHS; MH-091351/MH/NIMH NIH HHS; NS-41298/NS/NINDS NIH HHS; R01 MH091351/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
WI4X0X7BPJ/Hydrocortisone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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