| Maternal corticotropin-releasing hormone levels during pregnancy and offspring adiposity. | |
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MedLine Citation:
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PMID: 17030976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Animal models suggest that fetal exposure to glucocorticoids can program adiposity, especially central adiposity, later in life. We examined associations of maternal corticotropin-releasing hormone (CRH) levels in the late 2nd trimester of pregnancy, a marker of fetal glucocorticoid exposure, with child adiposity at age 3 years. RESEARCH METHODS AND PROCEDURES: We analyzed data from 199 participants in Project Viva, a prospective cohort study of pregnant women and their children, At age 3 years, the main outcomes were age-sex-specific BMI z score and the sum of subscapular (SS) and triceps (TR) skinfold thicknesses to represent overall adiposity, and ratio of SS to TR (SS:TR) to represent central adiposity. RESULTS: Mean (standard deviation) maternal 2nd trimester log CRH was 4.94 (0.56) pg/mL. At age 3, mean (standard deviation) for BMI z score was 0.52 (1.02); for SS + TR, 16.51 (3.94) mm; and for SS:TR, 0.67 (0.17). Log CRH was mildly inversely correlated with birth weight (r = -0.08), chiefly because of its association with length of gestation (r = -0.21) rather than fetal growth (r = -0.004). After adjustment for sociodemographic factors, maternal smoking, BMI, and gestational weight gain, fetal growth, length of gestation, breastfeeding duration, and (for SS:TR only) child's 3-year BMI, each increment of 1 unit of log CRH was associated with a reduction in BMI z score [-0.43; 95% confidence interval (CI), -0.73, -0.14; p = 0.004] and possible reduction in SS + TR (-1.10; 95% CI, -2.33, 0.14; p = 0.08). In contrast, log CRH was associated with higher SS:TR (0.07; 95% CI, 0.02, 0.13; p = 0.007). DISCUSSION: Fetal exposure to glucocorticoids, although associated with an overall decrease in body size, may cause an increase in central adiposity. |
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Authors:
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Matthew W Gillman; Janet W Rich-Edwards; Susanna Huh; Joseph A Majzoub; Emily Oken; Elsie M Taveras; Sheryl L Rifas-Shiman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 14 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-10-10 Completed Date: 2007-01-16 Revised Date: 2011-10-19 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 1647-53 Citation Subset: IM |
Affiliation:
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Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA. matthew_gillman@hms.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity* Body Mass Index Child, Preschool Cohort Studies Corticotropin-Releasing Hormone / blood* Female Humans Infant Male Maternal Behavior Obesity / epidemiology*, etiology Pregnancy / blood* Prenatal Exposure Delayed Effects / physiopathology* Prospective Studies Risk Factors Skinfold Thickness |
| Grant Support | |
ID/Acronym/Agency:
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HD 34568/HD/NICHD NIH HHS; HD 44807/HD/NICHD NIH HHS; HL 64925/HL/NHLBI NIH HHS; HL 68041/HL/NHLBI NIH HHS; HL 75504/HL/NHLBI NIH HHS; K23 HD044807-04/HD/NICHD NIH HHS; K23 HD044807-05/HD/NICHD NIH HHS; K24 HL068041-05/HL/NHLBI NIH HHS; P30 DK040561-11/DK/NIDDK NIH HHS; R01 HD034568-05/HD/NICHD NIH HHS; R01 HL064925-04/HL/NHLBI NIH HHS; R01 HL075504-04/HL/NHLBI NIH HHS; RR02172/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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9015-71-8/Corticotropin-Releasing Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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