Document Detail


Maternal corticotropin-releasing hormone levels during pregnancy and offspring adiposity.
MedLine Citation:
PMID:  17030976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Animal models suggest that fetal exposure to glucocorticoids can program adiposity, especially central adiposity, later in life. We examined associations of maternal corticotropin-releasing hormone (CRH) levels in the late 2nd trimester of pregnancy, a marker of fetal glucocorticoid exposure, with child adiposity at age 3 years.
RESEARCH METHODS AND PROCEDURES: We analyzed data from 199 participants in Project Viva, a prospective cohort study of pregnant women and their children, At age 3 years, the main outcomes were age-sex-specific BMI z score and the sum of subscapular (SS) and triceps (TR) skinfold thicknesses to represent overall adiposity, and ratio of SS to TR (SS:TR) to represent central adiposity.
RESULTS: Mean (standard deviation) maternal 2nd trimester log CRH was 4.94 (0.56) pg/mL. At age 3, mean (standard deviation) for BMI z score was 0.52 (1.02); for SS + TR, 16.51 (3.94) mm; and for SS:TR, 0.67 (0.17). Log CRH was mildly inversely correlated with birth weight (r = -0.08), chiefly because of its association with length of gestation (r = -0.21) rather than fetal growth (r = -0.004). After adjustment for sociodemographic factors, maternal smoking, BMI, and gestational weight gain, fetal growth, length of gestation, breastfeeding duration, and (for SS:TR only) child's 3-year BMI, each increment of 1 unit of log CRH was associated with a reduction in BMI z score [-0.43; 95% confidence interval (CI), -0.73, -0.14; p = 0.004] and possible reduction in SS + TR (-1.10; 95% CI, -2.33, 0.14; p = 0.08). In contrast, log CRH was associated with higher SS:TR (0.07; 95% CI, 0.02, 0.13; p = 0.007).
DISCUSSION: Fetal exposure to glucocorticoids, although associated with an overall decrease in body size, may cause an increase in central adiposity.
Authors:
Matthew W Gillman; Janet W Rich-Edwards; Susanna Huh; Joseph A Majzoub; Emily Oken; Elsie M Taveras; Sheryl L Rifas-Shiman
Related Documents :
20200806 - Upper respiratory tract infection during pregnancy: is it associated with adverse perin...
9240576 - Fetal fibronectin as a predictor of preterm birth in patients with symptoms: a multicen...
18426516 - Influences of study design and location on the relationship between particulate matter ...
19474476 - Pregnancy outcomes in women with hiv type-1 receiving a lopinavir/ritonavir-containing ...
10758226 - Diabetic retinopathy in pregnancy: effects on the natural course.
8092226 - Swallowing of lung liquid and amniotic fluid by the ovine fetus under normoxic and hypo...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  14     ISSN:  1930-7381     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-10-10     Completed Date:  2007-01-16     Revised Date:  2011-10-19    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1647-53     Citation Subset:  IM    
Affiliation:
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA. matthew_gillman@hms.harvard.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adiposity*
Body Mass Index
Child, Preschool
Cohort Studies
Corticotropin-Releasing Hormone / blood*
Female
Humans
Infant
Male
Maternal Behavior
Obesity / epidemiology*,  etiology
Pregnancy / blood*
Prenatal Exposure Delayed Effects / physiopathology*
Prospective Studies
Risk Factors
Skinfold Thickness
Grant Support
ID/Acronym/Agency:
HD 34568/HD/NICHD NIH HHS; HD 44807/HD/NICHD NIH HHS; HL 64925/HL/NHLBI NIH HHS; HL 68041/HL/NHLBI NIH HHS; HL 75504/HL/NHLBI NIH HHS; K23 HD044807-04/HD/NICHD NIH HHS; K23 HD044807-05/HD/NICHD NIH HHS; K24 HL068041-05/HL/NHLBI NIH HHS; P30 DK040561-11/DK/NIDDK NIH HHS; R01 HD034568-05/HD/NICHD NIH HHS; R01 HL064925-04/HL/NHLBI NIH HHS; R01 HL075504-04/HL/NHLBI NIH HHS; RR02172/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
9015-71-8/Corticotropin-Releasing Hormone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Long-term effects of obesity on employment and work limitations among U.S. Adults, 1986 to 1999.
Next Document:  Impaired lung function is associated with obesity and metabolic syndrome in adults.