| Maternal corticotropin-releasing hormone and habituation in the human fetus. | |
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MedLine Citation:
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PMID: 10204092 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elevated concentrations of maternal corticotrophin-releasing hormone (CRH) during the 2nd and early 3rd trimester of human pregnancy are associated with spontaneous preterm birth, but the effects of maternal CRH on the fetus are unknown. Maternal plasma was collected for analysis of CRH concentration, m = 156.24 +/- 130.91 pg/ml, from 33 pregnant women during Weeks 31-33 of gestation. Immediately after collection of plasma, fetal heart rate (FHR) measures were obtained in response to a challenge with a series of vibroacoustic stimuli. Fetuses of mothers with highly elevated CRH did not respond significantly to the presence of a novel stimulus in a repeated series, p = 0.016. These effects on the FHR response were not related to parity, fetal gender, medical (antepartum) risk, or eventual birth outcomes. Impaired dishabituation in these fetuses of mothers with high concentrations of CRH suggests that neurological systems rich with CRH receptors that support learning and memory, such as parahippocampal regions, may be targets for maternal/placental CRH, with implications for fetal neurological development. |
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Authors:
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C A Sandman; P D Wadhwa; A Chicz-DeMet; M Porto; T J Garite |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Developmental psychobiology Volume: 34 ISSN: 0012-1630 ISO Abbreviation: Dev Psychobiol Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-06-02 Completed Date: 1999-06-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0164074 Medline TA: Dev Psychobiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 163-73 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of California, Irvine 92697, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Adult Corticotropin-Releasing Hormone / blood* Embryonic and Fetal Development / physiology* Female Habituation, Psychophysiologic / physiology* Heart Rate, Fetal / physiology* Humans Infant, Newborn Labor, Obstetric Male Maternal-Fetal Exchange / physiology* Pregnancy Pregnancy Trimester, Third / blood* Ultrasonography, Prenatal Uterine Contraction / physiology |
| Grant Support | |
ID/Acronym/Agency:
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P30 HD 28202/HD/NICHD NIH HHS; R01 HD 28413/HD/NICHD NIH HHS; R29 HD 33506/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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