Document Detail


Maternal corticotropin-releasing hormone and habituation in the human fetus.
MedLine Citation:
PMID:  10204092     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elevated concentrations of maternal corticotrophin-releasing hormone (CRH) during the 2nd and early 3rd trimester of human pregnancy are associated with spontaneous preterm birth, but the effects of maternal CRH on the fetus are unknown. Maternal plasma was collected for analysis of CRH concentration, m = 156.24 +/- 130.91 pg/ml, from 33 pregnant women during Weeks 31-33 of gestation. Immediately after collection of plasma, fetal heart rate (FHR) measures were obtained in response to a challenge with a series of vibroacoustic stimuli. Fetuses of mothers with highly elevated CRH did not respond significantly to the presence of a novel stimulus in a repeated series, p = 0.016. These effects on the FHR response were not related to parity, fetal gender, medical (antepartum) risk, or eventual birth outcomes. Impaired dishabituation in these fetuses of mothers with high concentrations of CRH suggests that neurological systems rich with CRH receptors that support learning and memory, such as parahippocampal regions, may be targets for maternal/placental CRH, with implications for fetal neurological development.
Authors:
C A Sandman; P D Wadhwa; A Chicz-DeMet; M Porto; T J Garite
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental psychobiology     Volume:  34     ISSN:  0012-1630     ISO Abbreviation:  Dev Psychobiol     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-02     Completed Date:  1999-06-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  163-73     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of California, Irvine 92697, USA.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Adult
Corticotropin-Releasing Hormone / blood*
Embryonic and Fetal Development / physiology*
Female
Habituation, Psychophysiologic / physiology*
Heart Rate, Fetal / physiology*
Humans
Infant, Newborn
Labor, Obstetric
Male
Maternal-Fetal Exchange / physiology*
Pregnancy
Pregnancy Trimester, Third / blood*
Ultrasonography, Prenatal
Uterine Contraction / physiology
Grant Support
ID/Acronym/Agency:
P30 HD 28202/HD/NICHD NIH HHS; R01 HD 28413/HD/NICHD NIH HHS; R29 HD 33506/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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