Document Detail


Maternal and cord steroid sex hormones, angiogenic factors, and insulin-like growth factor axis in African-American preeclamptic and uncomplicated pregnancies.
MedLine Citation:
PMID:  22418778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A history of a preeclamptic pregnancy has been associated with subsequent increased risk of cardiovascular disease in the mother and decreased risk of breast cancer in both the mother and offspring. The concentrations of steroid sex hormones, angiogenic factors, and other proteins during pregnancy are important components of the in utero environment and may mediate the association of preeclampsia with later health outcomes. This study sought to compare an extensive profile of biological markers in both maternal and umbilical cord samples in preeclamptic and uncomplicated pregnancies of a predominantly African-American population.
METHODS: Steroid sex hormones, angiogenic factors, and components of the insulin-like growth factor axis were measured in maternal and umbilical cord sera from 48 pregnancies complicated by preeclampsia and 43 uncomplicated pregnancies. Regression models estimated the associations of these markers with preeclampsia, after adjusting for maternal and gestational age.
RESULTS: Concentrations of androgens (testosterone p = 0.06 and androstenedione p = 0.08) and the anti-angiogenic factors soluble fms-like kinase 1 (p = 0.004) and soluble endoglin (p = 0.004) were higher in the maternal circulation of women diagnosed with preeclampsia. These findings also were noted when the analyses were restricted to only African-American participants (77% of overall study population). Furthermore, among African-Americans, cord insulin-like growth factor-1 was lower in preeclamptic pregnancies than in controls.
CONCLUSIONS: The associations of maternal androgens and anti-angiogenic factors with preeclampsia are consistent with prior reports from predominantly Caucasian populations. Alterations in these analytes as well as other maternal and fetal biomarkers in preeclampsia could mediate the associations of preeclampsia with later health consequences.
Authors:
Jessica M Faupel-Badger; Yuping Wang; Anne Cathrine Staff; S Ananth Karumanchi; Frank Z Stanczyk; Michael Pollak; Robert N Hoover; Rebecca Troisi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2012-03-15
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  23     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-26     Completed Date:  2012-10-22     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  779-84     Citation Subset:  IM    
Affiliation:
Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, Bethesda, MD 20892-7105, USA. badgerje@mail.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Americans*
Angiogenic Proteins / blood*
Case-Control Studies
Female
Fetal Blood / chemistry,  metabolism
Gonadal Steroid Hormones / blood*
Humans
Insulin-Like Growth Factor I / metabolism
Neovascularization, Physiologic
Pre-Eclampsia / blood*,  ethnology*
Pregnancy
Prolactin / blood
Somatomedins / metabolism*
Vascular Endothelial Growth Factor Receptor-1 / blood
Young Adult
Grant Support
ID/Acronym/Agency:
Z99 CA999999/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Angiogenic Proteins; 0/Gonadal Steroid Hormones; 0/Somatomedins; 67763-96-6/Insulin-Like Growth Factor I; 9002-62-4/Prolactin; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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