Document Detail

Maternal complication of pregnancy in Marfan syndrome.
MedLine Citation:
PMID:  18632169     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Evaluate the risk of aortic complications (aortic dissection or prophylactic aortic surgical replacement) associated with pregnancy in Marfan syndrome in the absence of specific care. BACKGROUND: Data are scarce on aortic complications during pregnancy in Marfan syndrome. METHODS: Retrospective study on a large population (415 patients) followed up in our multidisciplinary out-patient clinic devoted to Marfan syndrome. Women over 18 years of age were divided into 2 groups: 85 had been pregnant (MFSP+) giving birth to 136 children through 160 pregnancies; 68 had not been pregnant (MFSP-). The occurrence of aortic complication was compared between the 2 groups using a piecewise discrete-time model. RESULTS: In MFSP+, 7 aortic complications occurred during 160 pregnancies (4.4%) and 17 aortic complications occurred during 1870 years of follow-up out of pregnancy. In MFSP-, 14 aortic complications occurred over 940 years of follow-up. Pregnancy was associated with a 5 fold increase in risk of aortic complication, which did not translate into increased risk during life, suggesting that pregnancy may act as a revealer in women prone to aortic complication. CONCLUSIONS: Pregnancy is associated with a transient increased risk of aortic complication in the absence of specific care.
Laure Pacini; Frank Digne; Ariane Boumendil; Christine Muti; Delphine Detaint; Catherine Boileau; Guillaume Jondeau
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Publication Detail:
Type:  Journal Article     Date:  2008-07-15
Journal Detail:
Title:  International journal of cardiology     Volume:  136     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  156-61     Citation Subset:  IM    
Centre de Référence National Syndrome de Marfan et Apparentés, Hôpital Bichat, AP-HP, Faculté Paris 7, 75018 Paris, France.
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MeSH Terms
Aneurysm, Dissecting / epidemiology*,  surgery
Aortic Aneurysm / epidemiology*,  surgery
Disease-Free Survival
Follow-Up Studies
Marfan Syndrome / epidemiology*
Middle Aged
Mitral Valve Insufficiency / epidemiology*,  surgery
Pregnancy Complications, Cardiovascular / epidemiology*
Retrospective Studies
Risk Factors
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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