| Maternal complication of pregnancy in Marfan syndrome. | |
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MedLine Citation:
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PMID: 18632169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Evaluate the risk of aortic complications (aortic dissection or prophylactic aortic surgical replacement) associated with pregnancy in Marfan syndrome in the absence of specific care. BACKGROUND: Data are scarce on aortic complications during pregnancy in Marfan syndrome. METHODS: Retrospective study on a large population (415 patients) followed up in our multidisciplinary out-patient clinic devoted to Marfan syndrome. Women over 18 years of age were divided into 2 groups: 85 had been pregnant (MFSP+) giving birth to 136 children through 160 pregnancies; 68 had not been pregnant (MFSP-). The occurrence of aortic complication was compared between the 2 groups using a piecewise discrete-time model. RESULTS: In MFSP+, 7 aortic complications occurred during 160 pregnancies (4.4%) and 17 aortic complications occurred during 1870 years of follow-up out of pregnancy. In MFSP-, 14 aortic complications occurred over 940 years of follow-up. Pregnancy was associated with a 5 fold increase in risk of aortic complication, which did not translate into increased risk during life, suggesting that pregnancy may act as a revealer in women prone to aortic complication. CONCLUSIONS: Pregnancy is associated with a transient increased risk of aortic complication in the absence of specific care. |
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Authors:
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Laure Pacini; Frank Digne; Ariane Boumendil; Christine Muti; Delphine Detaint; Catherine Boileau; Guillaume Jondeau |
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Publication Detail:
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Type: Journal Article Date: 2008-07-15 |
Journal Detail:
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Title: International journal of cardiology Volume: 136 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-27 Completed Date: 2009-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 156-61 Citation Subset: IM |
Affiliation:
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Centre de Référence National Syndrome de Marfan et Apparentés, Hôpital Bichat, AP-HP, Faculté Paris 7, 75018 Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aneurysm, Dissecting / epidemiology*, surgery Aortic Aneurysm / epidemiology*, surgery Disease-Free Survival Female Follow-Up Studies Humans Marfan Syndrome / epidemiology* Middle Aged Mitral Valve Insufficiency / epidemiology*, surgery Pregnancy Pregnancy Complications, Cardiovascular / epidemiology* Retrospective Studies Risk Factors Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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