Document Detail

Maternal collagen vascular disease associated with fetal heart block and degenerative changes of the atrioventricular valves.
MedLine Citation:
PMID:  7991440     Owner:  NLM     Status:  MEDLINE    
We report the case of a fetus diagnosed at 24 weeks' gestation with complete heart block associated with maternal collagen vascular disease and Sjögren's antibody. Serial fetal echocardiograms noted increased echogenicity along the tricuspid and mitral valves without insufficiency. Postnatally, severe tricuspid insufficiency occurred following placement of an endocardial pacing lead, and severe mitral insufficiency occurred acutely at 2.5 months of age. Both valves were noted at surgery to have fibrotic and calcific chordae tendineae that had ruptured from their papillary muscles. An inflammatory reaction within the fetal heart related to transplacental passage of Sjögren's antibody was likely responsible.
H S Weber; J L Myers
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric cardiology     Volume:  15     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    1994 Jul-Aug
Date Detail:
Created Date:  1995-01-12     Completed Date:  1995-01-12     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-6     Citation Subset:  IM    
Section of Pediatric Cardiology, Pennsylvania State University Childrens Hospital, Hershey.
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MeSH Terms
Autoantibodies / analysis
Chordae Tendineae / pathology,  surgery
Collagen Diseases / diagnosis*,  pathology,  surgery
Heart Block / diagnosis*,  pathology,  surgery
Heart Valve Prosthesis
Infant, Newborn
Maternal-Fetal Exchange / physiology
Mitral Valve / pathology,  surgery
Mitral Valve Insufficiency / diagnosis*,  pathology,  surgery
Papillary Muscles / pathology,  surgery
Pregnancy Complications, Cardiovascular / diagnosis*,  pathology,  surgery
Rupture, Spontaneous
Sjogren's Syndrome / diagnosis*,  pathology,  surgery
Tricuspid Valve / pathology,  surgery
Tricuspid Valve Insufficiency / diagnosis*,  pathology,  surgery
Ultrasonography, Prenatal
Reg. No./Substance:

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