Document Detail


Maternal cocaine use and genitourinary tract malformations.
MedLine Citation:
PMID:  3368874     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A specific fetal disruption syndrome associated with maternal cocaine use has not as yet been documented. In the first 23 pregnancies evaluated in our program for chemically dependent women, one infant with prune belly syndrome and one infant with hypospadias were delivered to cocaine-using women. In the present study, all infants delivered in our program received a renal ultrasound at 2-3 days of life. Fifty infants born to cocaine-using women (group I) and 30 born to polydrug, noncocaine-using women (group II) were evaluated. The two groups of women were similar for age, gravidity, and race. Mean birth weight of the infants in the two groups was similar. Seven infants in group I demonstrated genitourinary tract malformations while there were no infants with such malformations in group II. It is hypothesized that the vasoconstrictive effects of cocaine could explain the abnormalities of the genitourinary tract found in the cocaine-exposed infants.
Authors:
I J Chasnoff; G M Chisum; W E Kaplan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Teratology     Volume:  37     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-06-13     Completed Date:  1988-06-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-4     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Northwestern University Medical School, Northwestern Memorial Hospital, Chicago, Illinois 60611.
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MeSH Terms
Descriptor/Qualifier:
Cocaine*
Female
Humans
Pregnancy
Prenatal Exposure Delayed Effects*
Substance-Related Disorders
Urogenital Abnormalities*
Grant Support
ID/Acronym/Agency:
1R01DA-04103-01/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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