| Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placenta. | |
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MedLine Citation:
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PMID: 20647767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal cigarette smoking during pregnancy is associated with poor fetal outcome and aberrant miRNA expression is associated with adverse pregnancy outcomes. In 25 human placentas, we analyzed the expression of four candidate miRNA previously implicated in growth and developmental processes: miR-16, miR-21, miR-146a, and miR-182, and used three immortalized placental cell lines to identify if specific components of cigarette smoke were responsible for alterations to miRNA expression. miR-16, miR-21, and miR-146a were significantly downregulated in cigarette smoke-exposed placentas compared to controls. TCL-1 cells exposed to both nicotine and benzo(a)pyrene exhibited significant, dose-dependent downregulation of miR-146a. These results suggest that miR-146a is particularly responsive to exposures, and that smoking may elicit some of its downstream effects through alteration of miRNA expression. |
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Authors:
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Matthew A Maccani; Michele Avissar-Whiting; Carolyn E Banister; Bethany McGonnigal; James F Padbury; Carmen J Marsit |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-01 |
Journal Detail:
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Title: Epigenetics : official journal of the DNA Methylation Society Volume: 5 ISSN: 1559-2308 ISO Abbreviation: Epigenetics Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2011-04-05 Completed Date: 2011-06-28 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 101265293 Medline TA: Epigenetics Country: United States |
Other Details:
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Languages: eng Pagination: 583-9 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Benzo(a)pyrene / toxicity Case-Control Studies Cell Line Down-Regulation / drug effects Female Humans Infant, Newborn Male MicroRNAs / genetics*, metabolism Nicotine / toxicity Placenta / drug effects, metabolism* Pregnancy Pregnancy Outcome Smoking / adverse effects*, genetics*, metabolism Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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NCRR-P20RR018728//PHS HHS; P20 RR018728-076588/RR/NCRR NIH HHS; P42 ES013660-056035/ES/NIEHS NIH HHS; P42ES013660/ES/NIEHS NIH HHS; T32 ES007272-19/ES/NIEHS NIH HHS; T32ES007272/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/MIRN146 microRNA, human; 0/MIRN16 microRNA, human; 0/MIRN21 microRNA, human; 0/MicroRNAs; 0/Mirn182 microRNA, human; 50-32-8/Benzo(a)pyrene; 54-11-5/Nicotine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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