Document Detail

Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placenta.
MedLine Citation:
PMID:  20647767     Owner:  NLM     Status:  MEDLINE    
Maternal cigarette smoking during pregnancy is associated with poor fetal outcome and aberrant miRNA expression is associated with adverse pregnancy outcomes. In 25 human placentas, we analyzed the expression of four candidate miRNA previously implicated in growth and developmental processes: miR-16, miR-21, miR-146a, and miR-182, and used three immortalized placental cell lines to identify if specific components of cigarette smoke were responsible for alterations to miRNA expression. miR-16, miR-21, and miR-146a were significantly downregulated in cigarette smoke-exposed placentas compared to controls. TCL-1 cells exposed to both nicotine and benzo(a)pyrene exhibited significant, dose-dependent downregulation of miR-146a. These results suggest that miR-146a is particularly responsive to exposures, and that smoking may elicit some of its downstream effects through alteration of miRNA expression.
Matthew A Maccani; Michele Avissar-Whiting; Carolyn E Banister; Bethany McGonnigal; James F Padbury; Carmen J Marsit
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-01
Journal Detail:
Title:  Epigenetics : official journal of the DNA Methylation Society     Volume:  5     ISSN:  1559-2308     ISO Abbreviation:  Epigenetics     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2011-04-05     Completed Date:  2011-06-28     Revised Date:  2013-07-19    
Medline Journal Info:
Nlm Unique ID:  101265293     Medline TA:  Epigenetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  583-9     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
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MeSH Terms
Benzo(a)pyrene / toxicity
Case-Control Studies
Cell Line
Down-Regulation / drug effects
Infant, Newborn
MicroRNAs / genetics*,  metabolism
Nicotine / toxicity
Placenta / drug effects,  metabolism*
Pregnancy Outcome
Smoking / adverse effects*,  genetics*,  metabolism
Young Adult
Grant Support
NCRR-P20RR018728//PHS HHS; P20 RR018728/RR/NCRR NIH HHS; P20 RR018728-076588/RR/NCRR NIH HHS; P42 ES013660/ES/NIEHS NIH HHS; P42 ES013660-056035/ES/NIEHS NIH HHS; P42ES013660/ES/NIEHS NIH HHS; T32 ES007272/ES/NIEHS NIH HHS; T32 ES007272-19/ES/NIEHS NIH HHS; T32ES007272/ES/NIEHS NIH HHS
Reg. No./Substance:
0/MIRN146 microRNA, human; 0/MIRN16 microRNA, human; 0/MIRN21 microRNA, human; 0/MicroRNAs; 0/Mirn182 microRNA, human; 50-32-8/Benzo(a)pyrene; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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