| Maternal cigarette smoking and the associated risk of having a child with orofacial clefts in China: A case-control study. | |
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MedLine Citation:
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PMID: 20832329 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: We investigated whether maternal and paternal cigarette smoking during early pregnancy could increase the risk of delivering an infant with an orofacial cleft. METHODS: A case-control study was carried out in China. 304 infants born with an isolated nonsyndromic oral cleft and 453 non-malformed controls were recruited as participants and their exposure to smoke plus family history data were collected. RESULTS: The relative odds ratios of maternal smoking to cause an orofacial cleft in infant increased for 3.30 (95% CI, 1.17-9.33) in CLO and 3.12 (95% CI, 1.24-7.84) in CLP from 1 to 10 cigarettes per day before pregnancy. The unadjusted odds ratio is 3.64 (95% CI, 1.01-13.19) and the adjusted OR is 7.00 (95% CI, 1.44-34.13) in CLO from 1 to 10 cigarettes during the first trimester. Paternal smoking in the periconceptional period was strongly associated with all subtypes of CLP. The association with medium ETS (2-6h) at home or at work was strongest for infants with all OFCs in the periconceptional period from 1 month before pregnancy through the end of the first trimester. CONCLUSION: This study confirmed the modest association between maternal smoking and orofacial clefts. |
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Authors:
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Bing Zhang; Xiaohui Jiao; Limin Mao; Jie Xue |
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Publication Detail:
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Type: Journal Article Date: 2010-09-15 |
Journal Detail:
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Title: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery Volume: 39 ISSN: 1878-4119 ISO Abbreviation: J Craniomaxillofac Surg Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8704309 Medline TA: J Craniomaxillofac Surg Country: Scotland |
Other Details:
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Languages: eng Pagination: 313-8 Citation Subset: D; IM |
Copyright Information:
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Copyright © 2010 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Oral and Maxillofacial Surgery, The Stomatology College of Harbin Medical University, YouZheng Street 23, NanGang District, Harbin 150001, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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