Document Detail

Maternal cigarette smoking and the associated risk of having a child with orofacial clefts in China: A case-control study.
MedLine Citation:
PMID:  20832329     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: We investigated whether maternal and paternal cigarette smoking during early pregnancy could increase the risk of delivering an infant with an orofacial cleft.
METHODS: A case-control study was carried out in China. 304 infants born with an isolated nonsyndromic oral cleft and 453 non-malformed controls were recruited as participants and their exposure to smoke plus family history data were collected.
RESULTS: The relative odds ratios of maternal smoking to cause an orofacial cleft in infant increased for 3.30 (95% CI, 1.17-9.33) in CLO and 3.12 (95% CI, 1.24-7.84) in CLP from 1 to 10 cigarettes per day before pregnancy. The unadjusted odds ratio is 3.64 (95% CI, 1.01-13.19) and the adjusted OR is 7.00 (95% CI, 1.44-34.13) in CLO from 1 to 10 cigarettes during the first trimester. Paternal smoking in the periconceptional period was strongly associated with all subtypes of CLP. The association with medium ETS (2-6h) at home or at work was strongest for infants with all OFCs in the periconceptional period from 1 month before pregnancy through the end of the first trimester.
CONCLUSION: This study confirmed the modest association between maternal smoking and orofacial clefts.
Bing Zhang; Xiaohui Jiao; Limin Mao; Jie Xue
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Publication Detail:
Type:  Journal Article     Date:  2010-09-15
Journal Detail:
Title:  Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery     Volume:  39     ISSN:  1878-4119     ISO Abbreviation:  J Craniomaxillofac Surg     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704309     Medline TA:  J Craniomaxillofac Surg     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  313-8     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2010 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
Department of Oral and Maxillofacial Surgery, The Stomatology College of Harbin Medical University, YouZheng Street 23, NanGang District, Harbin 150001, China.
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