| Maternal and child's vitamin D supplement use and vitamin D level in relation to childhood lung function: the KOALA Birth Cohort Study. | |
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MedLine Citation:
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PMID: 21422038 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background Vitamin D is associated with lung function in adults, but its relation with childhood lung function is still unclear. Objective To investigate whether prenatal and postnatal vitamin D supplementation and plasma level is associated with childhood lung function. Methods In the KOALA Birth Cohort Study, children's lung function (n=436) was measured at age 6-7 years by means of spirometry and presented as forced expiratory volume in 1 s (FEV(1)) z scores and forced vital capacity z scores. The mother and child's 25-hydroxyvitamin D plasma level was determined around 36 weeks of pregnancy and at age 2 years. Vitamin D supplement intake during pregnancy was defined based on the amount of vitamin D in supplements, and trimester and duration of use. Data on child's vitamin D supplement use were collected through questionnaires at ages 1, 2 and 6-7 years. Results 25-Hydroxyvitamin D level and vitamin D supplement use in childhood were not associated with lung function. Maternal use of vitamin D at <10 μg/day (adjusted beta (AdjB -0.37; 95% CI -0.69 to -0.05)), vitamin D containing multivitamin use in the second and/or third trimester (AdjB -0.26; 95% CI -0.49 to -0.03), and use for two trimesters (AdjB -0.25; 95% CI -0.49 to -0.02) were associated with a significantly lower FEV(1) z score compared with no supplements. Maternal use of vitamin D at ≥10 μg/day and use in the first or all trimesters was not associated with significantly lower lung function levels. Conclusion The authors found no association between 25-hydroxyvitamin D levels, vitamin D supplementation in childhood or recommended vitamin D dosage of ≥10 μg/day during pregnancy and lung function in children aged 6-7 years. |
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Authors:
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Elleke Cremers; Carel Thijs; John Penders; Eugene Jansen; Monique Mommers |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-21 |
Journal Detail:
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Title: Thorax Volume: - ISSN: 1468-3296 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417353 Medline TA: Thorax Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Epidemiology, Maastricht University, CAPHRI School for Public Health and Primary Care, Maastricht, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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