Document Detail

Maternal and child's vitamin D supplement use and vitamin D level in relation to childhood lung function: the KOALA Birth Cohort Study.
MedLine Citation:
PMID:  21422038     Owner:  NLM     Status:  Publisher    
Background Vitamin D is associated with lung function in adults, but its relation with childhood lung function is still unclear. Objective To investigate whether prenatal and postnatal vitamin D supplementation and plasma level is associated with childhood lung function. Methods In the KOALA Birth Cohort Study, children's lung function (n=436) was measured at age 6-7&emsp14;years by means of spirometry and presented as forced expiratory volume in 1&emsp14;s (FEV(1)) z scores and forced vital capacity z scores. The mother and child's 25-hydroxyvitamin D plasma level was determined around 36&emsp14;weeks of pregnancy and at age 2&emsp14;years. Vitamin D supplement intake during pregnancy was defined based on the amount of vitamin D in supplements, and trimester and duration of use. Data on child's vitamin D supplement use were collected through questionnaires at ages 1, 2 and 6-7&emsp14;years. Results 25-Hydroxyvitamin D level and vitamin D supplement use in childhood were not associated with lung function. Maternal use of vitamin D at <10&emsp14;μg/day (adjusted beta (AdjB -0.37; 95% CI -0.69 to -0.05)), vitamin D containing multivitamin use in the second and/or third trimester (AdjB -0.26; 95% CI -0.49 to -0.03), and use for two trimesters (AdjB -0.25; 95% CI -0.49 to -0.02) were associated with a significantly lower FEV(1) z score compared with no supplements. Maternal use of vitamin D at ≥10&emsp14;μg/day and use in the first or all trimesters was not associated with significantly lower lung function levels. Conclusion The authors found no association between 25-hydroxyvitamin D levels, vitamin D supplementation in childhood or recommended vitamin D dosage of ≥10&emsp14;μg/day during pregnancy and lung function in children aged 6-7&emsp14;years.
Elleke Cremers; Carel Thijs; John Penders; Eugene Jansen; Monique Mommers
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-21
Journal Detail:
Title:  Thorax     Volume:  -     ISSN:  1468-3296     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Epidemiology, Maastricht University, CAPHRI School for Public Health and Primary Care, Maastricht, The Netherlands.
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