| Maternal cell-mediated immunity in normal and pre-eclamptic pregnancy. | |
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MedLine Citation:
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PMID: 6219835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal cell-mediated immunity (CMI) to fetal (paternal) HLA was studied in both normal and pre-eclamptic pregnancies. Maternal-paternal mixed lymphocyte reactivity (MLR) was assessed using macrophage migration inhibitory factor (MIF), leucocyte migration inhibitory factor (LIF) and blast transformation assays. Primary and secondary responses were differentiated by studying 6 day MLR time courses. Maternal lymphocytes (normal pregnancies) did not show an early, (i.e. secondary), proliferative response, nor did the pattern of LIF release suggest maternal CMI to fetal (paternal) HLA. However, the lymphocyte responses between pre-eclamptic couples, in terms of both proliferation and LIF release, were consistently and significantly different from those of normal couples; a finding which may reflect an abnormal immune response. |
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Authors:
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I L Sargent; C W Redman; G M Stirrat |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 50 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 1982 Dec |
Date Detail:
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Created Date: 1983-05-05 Completed Date: 1983-05-05 Revised Date: 2012-09-18 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 601-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female HLA Antigens / immunology* Humans Immunity, Cellular Leukocyte Migration-Inhibitory Factors / immunology Lymphocyte Activation* Lymphocyte Culture Test, Mixed Male Maternal-Fetal Exchange Pre-Eclampsia / immunology*, metabolism Pregnancy Thymidine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/Leukocyte Migration-Inhibitory Factors; 50-89-5/Thymidine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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