Document Detail


Maternal cell-mediated immunity in normal and pre-eclamptic pregnancy.
MedLine Citation:
PMID:  6219835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal cell-mediated immunity (CMI) to fetal (paternal) HLA was studied in both normal and pre-eclamptic pregnancies. Maternal-paternal mixed lymphocyte reactivity (MLR) was assessed using macrophage migration inhibitory factor (MIF), leucocyte migration inhibitory factor (LIF) and blast transformation assays. Primary and secondary responses were differentiated by studying 6 day MLR time courses. Maternal lymphocytes (normal pregnancies) did not show an early, (i.e. secondary), proliferative response, nor did the pattern of LIF release suggest maternal CMI to fetal (paternal) HLA. However, the lymphocyte responses between pre-eclamptic couples, in terms of both proliferation and LIF release, were consistently and significantly different from those of normal couples; a finding which may reflect an abnormal immune response.
Authors:
I L Sargent; C W Redman; G M Stirrat
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  50     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2012-09-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  601-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Female
HLA Antigens / immunology*
Humans
Immunity, Cellular
Leukocyte Migration-Inhibitory Factors / immunology
Lymphocyte Activation*
Lymphocyte Culture Test, Mixed
Male
Maternal-Fetal Exchange
Pre-Eclampsia / immunology*,  metabolism
Pregnancy
Thymidine / metabolism
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/Leukocyte Migration-Inhibitory Factors; 50-89-5/Thymidine
Comments/Corrections

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