| Maternal cardiovascular changes during pregnancy and postpartum in mice. | |
| | |
MedLine Citation:
|
PMID: 11834487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Genetically altered mice may provide useful models for exploring cardiovascular regulation during pregnancy and postpartum if changes in mice mimic humans. We found in awake ICR (CD-1) mice at 17.5 days gestation that hematocrit was reduced 18%, and the pressor response to intravenous angiotensin II was reduced ~33%. Arterial pressure in awake mice was 12% lower in early pregnancy (3.5 days) than late pregnancy (17.5 days) and postpartum (3 and 17 days after delivery), whereas heart rate was 10-20% higher in the peripartum period (17.5 days gestation and 3 days postpartum). In late pregnancy, cardiac output under isoflurane anesthesia was 64% higher than in nonpregnant mice, due to a 37% increase in stroke volume and a 17% increase in heart rate. All changes P < 0.05. We conclude that, as in humans, mice exhibit hypotension in early pregnancy, and a blunted pressor response to angiotensin II, a decrease in hematocrit, and a marked increase in cardiac output in late pregnancy. |
| | |
Authors:
|
Alan Y H Wong; Shathiyah Kulandavelu; Kathie J Whiteley; Dawei Qu; B Lowell Langille; S Lee Adamson |
Related Documents
:
|
20842567 - Cardiac arrhythmias during pregnancy. 22851337 - 450k epigenome-wide scan identifies differential dna methylation in newborns related to... 23244997 - 163 effect of puerperal metritis on reproductive and productive performance in dairy co... 21210447 - Prediction of early, intermediate and late pre-eclampsia from maternal factors, biophys... 8811617 - Gestational age determination, variation of conception date, and external fetal develop... 23400357 - Plasma lipids and lipoproteins during pregnancy and related pregnancy outcomes. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: 282 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2002 Mar |
Date Detail:
|
Created Date: 2002-02-08 Completed Date: 2002-04-03 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: H918-25 Citation Subset: IM |
Affiliation:
|
Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, M5G 1X5, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Flow Velocity Blood Pressure Cardiac Output Cardiovascular Physiological Phenomena* Female Heart Rate Hematocrit Hemodynamics / physiology* Mice Mice, Inbred ICR Postpartum Period / physiology* Pregnancy Pregnancy, Animal / physiology* Reference Values Stroke Volume |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Potassium (BK(Ca)) currents are reduced in microvascular smooth muscle cells from insulin-resistant ...
Next Document: Differential expression of TNF-alpha, IL-6, and IGF-1 by graded mechanical stress in normal rat myoc...