Document Detail


Maternal cardiovascular changes during pregnancy and postpartum in mice.
MedLine Citation:
PMID:  11834487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetically altered mice may provide useful models for exploring cardiovascular regulation during pregnancy and postpartum if changes in mice mimic humans. We found in awake ICR (CD-1) mice at 17.5 days gestation that hematocrit was reduced 18%, and the pressor response to intravenous angiotensin II was reduced ~33%. Arterial pressure in awake mice was 12% lower in early pregnancy (3.5 days) than late pregnancy (17.5 days) and postpartum (3 and 17 days after delivery), whereas heart rate was 10-20% higher in the peripartum period (17.5 days gestation and 3 days postpartum). In late pregnancy, cardiac output under isoflurane anesthesia was 64% higher than in nonpregnant mice, due to a 37% increase in stroke volume and a 17% increase in heart rate. All changes P < 0.05. We conclude that, as in humans, mice exhibit hypotension in early pregnancy, and a blunted pressor response to angiotensin II, a decrease in hematocrit, and a marked increase in cardiac output in late pregnancy.
Authors:
Alan Y H Wong; Shathiyah Kulandavelu; Kathie J Whiteley; Dawei Qu; B Lowell Langille; S Lee Adamson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  282     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-08     Completed Date:  2002-04-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H918-25     Citation Subset:  IM    
Affiliation:
Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, M5G 1X5, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity
Blood Pressure
Cardiac Output
Cardiovascular Physiological Phenomena*
Female
Heart Rate
Hematocrit
Hemodynamics / physiology*
Mice
Mice, Inbred ICR
Postpartum Period / physiology*
Pregnancy
Pregnancy, Animal / physiology*
Reference Values
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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