Document Detail

Maternal calorie restriction modulates placental mitochondrial biogenesis and bioenergetic efficiency: involvement in feto-placental growth defects in rats.
MedLine Citation:
PMID:  23092912     Owner:  NLM     Status:  Publisher    
Low birth weight is associated with an increased risk to develop type 2 diabetes and metabolic diseases. The placental capacity to supply nutrients and oxygen to the fetus represents the main determiner of fetal growth. However, few studies have investigated the effects of maternal diet on the placenta. We explored placental adaptive proteomic processes implicated in response to maternal undernutrition. Rat term placentas from 70% food-restricted (FR30) mothers were used for a proteomic screen. Placental mitochondrial functions were evaluated using molecular and functional approaches and ATP production was measured. FR30 drastically reduced placental and fetal weights. FR30 placentas displayed 14 proteins differentially expressed, including several mitochondrial proteins. FR30 induced a marked increase of placental mtDNA content and changes in mitochondrial functions including modulation of the expression of genes implicated in biogenesis and bioenergetic pathways. FR30 mitochondria showed higher oxygen consumption but fail to maintain their ATP production. Maternal undernutrition induces placental mitochondrial abnormalities. Although an increase of biogenesis and bioenergetic efficiency was noted, placental ATP level was reduced. Our data suggest that placental mitochondrial defects may be implicated in feto-placental pathologies.
Sylvain Mayeur; Steve Lancel; Nicolas Theys; Marie-Amelie Lukaszewski; Sophie Duban; Bruno Bastide; Johan Hachani; Roméo Cecchelli; Christophe Breton; Anne Gabory; Laurent Storme; Brigitte Reusens; Claudine Junien; Didier Vieau; Jean Lesage
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-23
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  -     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Unité environnement périnatal et croissance (EA 4489.
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