| Maternal caffeine intake from coffee and tea, fetal growth, and the risks of adverse birth outcomes: the Generation R Study. | |
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MedLine Citation:
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PMID: 20427730 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Caffeine is a widely used and accepted pharmacologically active substance. The effect of caffeine intake during pregnancy on fetal growth and development is still unclear. OBJECTIVE: We examined the associations of maternal caffeine intake, on the basis of coffee and tea consumption, with fetal growth characteristics measured in each trimester of pregnancy and the risks of adverse birth outcomes. DESIGN: Associations were studied in 7346 pregnant women participating in a population-based prospective cohort study from early pregnancy onward in the Netherlands (2001-2005). Caffeine intake in the first, second, and third trimesters was on the basis of coffee and tea consumption and was assessed by questionnaires. Fetal growth characteristics were repeatedly measured by ultrasound. Information about birth outcomes was obtained from hospital records. RESULTS: We observed no consistent associations of caffeine intake with fetal head circumference or estimated fetal weight in any trimester. Higher caffeine intake was associated with smaller first-trimester crown-rump length, second- and third-trimester femur length, and birth length (P for trend <0.05). Offspring of mothers who consumed > or =6 caffeine units/d tended to have increased risks of small-for-gestational-age infants at birth. CONCLUSIONS: Our results suggest that caffeine intake of > or =6 units/d during pregnancy is associated with impaired fetal length growth. Caffeine exposure might preferentially adversely affect fetal skeletal growth. Further studies are needed to assess these associations in non-European populations and to assess the postnatal consequences. |
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Authors:
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Rachel Bakker; Eric A P Steegers; Aleksandra Obradov; Hein Raat; Albert Hofman; Vincent W V Jaddoe |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-28 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 91 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-06-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1691-8 Citation Subset: AIM; IM |
Affiliation:
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Departments of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Birth Weight / drug effects Caffeine / administration & dosage*, adverse effects* Coffee / adverse effects Cohort Studies Dose-Response Relationship, Drug Female Fetal Development / drug effects*, physiology Humans Infant, Newborn Male Maternal Exposure / adverse effects* Middle Aged Pregnancy Pregnancy Outcome Prospective Studies Questionnaires Tea / adverse effects Ultrasonography, Prenatal Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Coffee; 0/Tea; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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