Document Detail

Maternal caffeine consumption and risk of neural tube defects.
MedLine Citation:
PMID:  19711421     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Animal studies demonstrate teratogenic effects of caffeine, whereas human studies are inconclusive.
METHODS: Associations between maternal caffeine consumption and neural tube defects (NTDs) by type of NTD (anencephaly, spina bifida, or encephalocele) were examined using data from the National Birth Defects Prevention Study (NBDPS). Total average daily caffeine from coffee, tea, soda, and chocolate consumption during the year before pregnancy was estimated for 768 mothers of infants with NTDs and 4143 mothers of infants without birth defects who gave birth during 1997 through 2002. Periconceptional use of caffeine-containing medications was evaluated separately. Adjusted odds ratios (OR) and 95% confidence intervals (CI) associated with consumption of total caffeine and each caffeine source were estimated from logistic regression models.
RESULTS: Positive associations were observed between spina bifida and total caffeine consumption (OR 1.4; 95% CI: 1.1-1.9) and each caffeine source except caffeinated tea, which showed a negative association with spina bifida (OR 0.7; 95% CI: 0.6-0.9). Associations with modestly increased risk of NTDs and encephalocele were also observed. The association between caffeine consumption and anencephaly differed by maternal race/ethnicity. No dose effects were found.
CONCLUSIONS: Additional studies should confirm whether women who consume caffeine are at increased risk for pregnancies complicated by NTDs.
Rebecca J Schmidt; Paul A Romitti; Trudy L Burns; Marilyn L Browne; Charlotte M Druschel; Richard S Olney;
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  85     ISSN:  1542-0760     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-17     Completed Date:  2010-01-25     Revised Date:  2011-02-09    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  879-89     Citation Subset:  IM    
Department of Psychiatry, University of California Davis Medical Center, University of California, Davis, CA, USA.
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MeSH Terms
Caffeine / administration & dosage*
Case-Control Studies
Maternal Exposure*
Neural Tube Defects / epidemiology*
Risk Factors
Grant Support
U50/CCU 713238//PHS HHS
Reg. No./Substance:
Comment In:
Birth Defects Res A Clin Mol Teratol. 2011 Jan;91(1):67; author reply 68   [PMID:  21254362 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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